Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese

• Main Authors: Ma R.C.W., Lee H.M., Lam V.K.L., Tam C.H.T., Ho J.S.K., Zhao H.-L., Guan J., Kong A.P.S., Lau E., Zhang G., Luk A., Wang Y., Tsui S.K.W., Chan T.F., Hu C., Jia W.P., Park K.S., Lee H.K., Furuta H., Nanjo K., Shyong Tai E., Ng D.P.-K., Tang N.L.S., Woo J., Leung P.C., Xue H., Wong J., Leung P.S., Lau T.C.K., Tong P.C.Y., Xu G., Ng M.C.Y., So W.Y., Chan J.C.N.
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: Public Library of Science 2020
• Subjects: insulin; DACH1 protein, human; eye protein; transcription factor; adult; article; Asian; autopsy; bioinformatics; cardiovascular disease; case control study; Chinese; cohort analysis; controlled study; coronary artery atherosclerosis; Dachshund homolog 1 gene; diabetes mellitus; familial young onset diabetes mellitus; female; gene; gene expression; genetic analysis; genetic association; genetic variability; human; human cell; human tissue; impaired glucose tolerance; insulin release; insulin resistance; intron; ischemic heart disease; major clinical study; male; molecular pathology; non insulin dependent diabetes mellitus; peripheral blood mononuclear cell; regulatory sequence; single nucleotide polymorphism; systolic blood pressure; aged; Asian continental ancestry group; Cardiovascular Diseases; Diabetes Mellitus, Type 2; genetic predisposition; genetics; genotype; middle aged; Prediabetic State; Aged; Asian Continental Ancestry Group; Case-Control Studies; Eye Proteins; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Transcription Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165964
• Institution: National University of Singapore

10.1371/journal.pone.0084770