Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

• Main Authors: Kanojia, D, Garg, M, Martinez, J, Anand, M.T, Luty, S.B, Doan, N.B, Said, J.W, Forscher, C, Tyner, J.W, Koeffler, H.P
• 其他作者: MEDICINE
• 格式: Article
• 出版: 2020
• 主題: 4 amino 5 (3 benzyloxyphenyl) 7 [3 (1 pyrrolidinylmethyl)cyclobutyl] 7h pyrrolo[2,3 d]pyrimidine; bortezomib; CD135 antigen; dasatinib; elesclomol; ephrin receptor A6; epidermal growth factor receptor; focal adhesion kinase 1; Janus kinase 1; Janus kinase 2; macrophage stimulating 1 receptor; megakaryocyte associated tyrosine kinase; phosphotransferase; platelet derived growth factor alpha receptor; ponatinib; protein kinase Fer; protein kinase Syk; protein tyrosine kinase; protein tyrosine kinase inhibitor; receptor tyrosine kinase like orphan receptor 1; RNA; ROS protooncogene 1 receptor tyrosine kinase; serine threonine tyrosine kinase 1; staurosporine; tanespimycin; tumor protein; unclassified drug; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog protein; vasculotropin receptor 2; imidazole derivative; protein kinase inhibitor; pyridazine derivative; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; cancer growth; cell cycle arrest; cell cycle G0 phase; cell cycle G1 phase; cell cycle S phase; clonogenesis; concentration response; controlled study; drug potency; drug screening; enzyme analysis; human; human cell; IC50; in vitro study; in vivo study; liposarcoma; mouse; nonhuman; protein targeting; RNA interference; signal transduction; animal; cell proliferation; nonobese diabetic mouse; preclinical study; SCID mouse; Animals; Cell Proliferation; Drug Evaluation, Preclinical; Humans; Imidazoles; Liposarcoma; Mice; Mice, Inbred NOD; Mice, SCID; Protein Kinase Inhibitors; Pyridazines; RNA Interference
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/173760

10.1186/s13045-017-0540-x