A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus

• Main Authors: Kumar D., Puan K.J., Andiappan A.K., Lee B., Westerlaken G.H.A., Haase D., Melchiotti R., Li Z., Yusof N., Lum J., Koh G., Foo S., Yeong J., Alves A.C., Pekkanen J., Sun L.D., Irwanto A., Fairfax B.P., Naranbhai V., Common J.E.A., Tang M., Chuang C.K., Jarvelin M.-R., Knight J.C., Zhang X., Chew F.T., Prabhakar S., Jianjun L., Wang D.Y., Zolezzi F., Poidinger M., Lane E.B., Meyaard L., Rötzschke O.
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: bisulfite; regulator protein; signal inhibitory receptor on leukocyte 1; transcription factor PU 1; transcription factor YY1; unclassified drug; immunoglobulin receptor; SIRL1 protein, human; adult; Article; atopic dermatitis; binding affinity; binding site; chromatin immunoprecipitation; cohort analysis; controlled study; CpG island; disease activity; disease association; DNA methylation; female; flow cytometry; gel mobility shift assay; gene; gene expression; gene frequency; gene function; gene identification; genetic association; genotype; human; human cell; male; molecular docking; molecular pathology; monocyte; promoter region; protein determination; protein DNA binding; protein expression; protein function; sequence analysis; single nucleotide polymorphism; upregulation; VSTM1 gene; Asian continental ancestry group; gene expression regulation; genetics; metabolism; young adult; Asian Continental Ancestry Group; Dermatitis, Atopic; DNA Methylation; Female; Gene Expression Regulation; Humans; Male; Monocytes; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, Immunologic; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173794
• Institution: National University of Singapore

10.1186/s13073-017-0404-6