Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway

• Main Authors: Leow S.M., Serene Chua S.X., Venkatachalam G., Shen L., Luo L., Clement M.-V.
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: caspase 3; cathepsin; gelsolin; hydrogen peroxide; lamin A; lamin C; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; transcription factor; transcription factor EB; unclassified drug; basic helix loop helix leucine zipper transcription factor; oxidizing agent; TFEB protein, rat; animal cell; apoptosis; Article; Atg9b gene; biogenesis; cell count; cell membrane permeability; cell nucleus; concentration (parameters); controlled study; Ctsb gene; Ctsl gene; cytosol; enzyme activation; enzyme substrate; gene; gene expression; gene silencing; genetic variability; intracellular transport; Lamp2 gene; Lamp2a gene; lysosome membrane; Neu1 gene; nonhuman; oxidative stress; phenotype; protein cleavage; protein function; protein transport; rat; RNA splicing; signal transduction; Sqstm1 gene; animal; cell line; cell survival; confocal microscopy; cytology; drug effects; genetics; immunoblotting; intracellular membrane; lysosome; metabolism; myoblast; nucleocytoplasmic transport; reverse transcription polymerase chain reaction; RNA interference; Active Transport, Cell Nucleus; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Caspase 3; Cathepsins; Cell Line; Cell Membrane Permeability; Cell Survival; Gene Expression; Hydrogen Peroxide; Immunoblotting; Intracellular Membranes; Lysosomes; Microscopy, Confocal; Myoblasts; Oxidants; Oxidative Stress; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173806
• Institution: National University of Singapore

10.18632/oncotarget.14016