XAF1 promotes neuroblastoma tumor suppression and is required for KIF1B?-mediated apoptosis

• Main Authors: Choo, Z, Koh, R.Y.L, Wallis, K, Koh, T.J.W, Kuick, C.H, Sobrado, V, Kenchappa, R.S, Loh, A.H.P, Soh, S.Y, Schlisio, S, Chang, K.T.E, Chen, Z.X
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: caspase 3; cell protein; kinesin; protein KIF1B beta; short hairpin RNA; unclassified drug; XIAP associated factor 1; F box protein; KIF1B protein, human; Kif1b protein, mouse; signal peptide; tumor marker; tumor protein; tumor suppressor protein; XAF1 protein, human; XAF1 protein, mouse; animal cell; animal experiment; animal model; animal tissue; apoptosis; Article; bioinformatics; cancer inhibition; cancer prognosis; cancer survival; cell viability; controlled study; disease status; female; gene silencing; general aspects of disease; genetic transfection; human; human cell; human tissue; in vitro study; in vivo study; knockout mouse; major clinical study; molecular dynamics; mouse; neuroblastoma; neuroprotection; nonhuman; overall survival; protein analysis; protein cleavage; protein expression; protein function; survival rate; survival time; tumor growth; tumor volume; animal; gene expression regulation; Kaplan Meier method; metabolism; mortality; pathology; physiology; prognosis; tumor cell line; xenograft; Animals; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; F-Box Proteins; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Kinesin; Mice; Mice, Knockout; Neoplasm Proteins; Neuroblastoma; Prognosis; Tumor Suppressor Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173827
• Institution: National University of Singapore

10.18632/oncotarget.8748