The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway

• Main Authors: Yan X., Wu H., Wu Z., Hua F., Liang D., Sun H., Yang Y., Huang D., Bian J.-S.
• Other Authors: DEPT OF CHEMISTRY
• Format: Article
• Published: Frontiers Media S.A. 2020
• Subjects: 3 (3,4 dihydroxyphenyl)lactic acid; alkaline phosphatase; caspase 3; collagen; glutathione; mitogen activated protein kinase; mitogen activated protein kinase 1; phosphatidylinositol 3 kinase; protein kinase B; reactive oxygen metabolite; sialoprotein; stress activated protein kinase; superoxide dismutase; synaptophysin; transcription factor RUNX2; adult; animal cell; animal experiment; antioxidant activity; apoptosis; Article; cell damage; cell differentiation; cell protection; cell viability; controlled study; drug structure; drug synthesis; enzyme activation; extracellular matrix; high performance liquid chromatography; in vitro study; in vivo study; molecular probe; mouse; MTT assay; nonhuman; osteoblast; oxidative stress; protein expression; proton nuclear magnetic resonance; quantitative analysis; rat; reverse transcription polymerase chain reaction; sustained drug release
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173871
• Institution: National University of Singapore

10.3389/fphar.2017.00007