The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway

10.3389/fphar.2017.00007

Saved in:

Bibliographic Details
Main Authors:	Yan X., Wu H., Wu Z., Hua F., Liang D., Sun H., Yang Y., Huang D., Bian J.-S.
Other Authors:	DEPT OF CHEMISTRY
Format:	Article
Published:	Frontiers Media S.A. 2020
Subjects:	3 (3,4 dihydroxyphenyl)lactic acid alkaline phosphatase caspase 3 collagen glutathione mitogen activated protein kinase mitogen activated protein kinase 1 phosphatidylinositol 3 kinase protein kinase B reactive oxygen metabolite sialoprotein stress activated protein kinase superoxide dismutase synaptophysin transcription factor RUNX2 adult animal cell animal experiment antioxidant activity apoptosis Article cell damage cell differentiation cell protection cell viability controlled study drug structure drug synthesis enzyme activation extracellular matrix high performance liquid chromatography in vitro study in vivo study molecular probe mouse MTT assay nonhuman osteoblast oxidative stress protein expression proton nuclear magnetic resonance quantitative analysis rat reverse transcription polymerase chain reaction sustained drug release
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173871
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

id	sg-nus-scholar.10635-173871
record_format	dspace
spelling	sg-nus-scholar.10635-1738712023-08-24T09:27:06Z The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway Yan X. Wu H. Wu Z. Hua F. Liang D. Sun H. Yang Y. Huang D. Bian J.-S. DEPT OF CHEMISTRY DEPT OF PHARMACOLOGY LIFE SCIENCES INSTITUTE SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH 3 (3,4 dihydroxyphenyl)lactic acid alkaline phosphatase caspase 3 collagen glutathione mitogen activated protein kinase mitogen activated protein kinase 1 phosphatidylinositol 3 kinase protein kinase B reactive oxygen metabolite sialoprotein stress activated protein kinase superoxide dismutase synaptophysin transcription factor RUNX2 adult animal cell animal experiment antioxidant activity apoptosis Article cell damage cell differentiation cell protection cell viability controlled study drug structure drug synthesis enzyme activation extracellular matrix high performance liquid chromatography in vitro study in vivo study molecular probe mouse MTT assay nonhuman osteoblast oxidative stress protein expression proton nuclear magnetic resonance quantitative analysis rat reverse transcription polymerase chain reaction sustained drug release 10.3389/fphar.2017.00007 Frontiers in Pharmacology 8 JAN 7 2020-09-01T08:02:18Z 2020-09-01T08:02:18Z 2017 Article Yan X., Wu H., Wu Z., Hua F., Liang D., Sun H., Yang Y., Huang D., Bian J.-S. (2017). The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway. Frontiers in Pharmacology 8 (JAN) : 7. ScholarBank@NUS Repository. https://doi.org/10.3389/fphar.2017.00007 16639812 https://scholarbank.nus.edu.sg/handle/10635/173871 Frontiers Media S.A. Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	3 (3,4 dihydroxyphenyl)lactic acid alkaline phosphatase caspase 3 collagen glutathione mitogen activated protein kinase mitogen activated protein kinase 1 phosphatidylinositol 3 kinase protein kinase B reactive oxygen metabolite sialoprotein stress activated protein kinase superoxide dismutase synaptophysin transcription factor RUNX2 adult animal cell animal experiment antioxidant activity apoptosis Article cell damage cell differentiation cell protection cell viability controlled study drug structure drug synthesis enzyme activation extracellular matrix high performance liquid chromatography in vitro study in vivo study molecular probe mouse MTT assay nonhuman osteoblast oxidative stress protein expression proton nuclear magnetic resonance quantitative analysis rat reverse transcription polymerase chain reaction sustained drug release
spellingShingle	3 (3,4 dihydroxyphenyl)lactic acid alkaline phosphatase caspase 3 collagen glutathione mitogen activated protein kinase mitogen activated protein kinase 1 phosphatidylinositol 3 kinase protein kinase B reactive oxygen metabolite sialoprotein stress activated protein kinase superoxide dismutase synaptophysin transcription factor RUNX2 adult animal cell animal experiment antioxidant activity apoptosis Article cell damage cell differentiation cell protection cell viability controlled study drug structure drug synthesis enzyme activation extracellular matrix high performance liquid chromatography in vitro study in vivo study molecular probe mouse MTT assay nonhuman osteoblast oxidative stress protein expression proton nuclear magnetic resonance quantitative analysis rat reverse transcription polymerase chain reaction sustained drug release Yan X. Wu H. Wu Z. Hua F. Liang D. Sun H. Yang Y. Huang D. Bian J.-S. The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway
description	10.3389/fphar.2017.00007
author2	DEPT OF CHEMISTRY
author_facet	DEPT OF CHEMISTRY Yan X. Wu H. Wu Z. Hua F. Liang D. Sun H. Yang Y. Huang D. Bian J.-S.
format	Article
author	Yan X. Wu H. Wu Z. Hua F. Liang D. Sun H. Yang Y. Huang D. Bian J.-S.
author_sort	Yan X.
title	The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway
title_short	The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway
title_full	The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway
title_fullStr	The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway
title_full_unstemmed	The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway
title_sort	new synthetic h2s-releasing sdss protects mc3t3-e1 osteoblasts against h2o2-induced apoptosis by suppressing oxidative stress, inhibiting mapks, and activating the pi3k/akt pathway
publisher	Frontiers Media S.A.
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173871
_version_	1778169652234420224

The new synthetic H2S-releasing SDSS protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K/Akt pathway

Similar Items