Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity

• Main Authors: Choudhury, Y, Toh, Y.C, Xing, J, Qu, Y, Poh, J, Huan, L, Tan, H.S, Kanesvaran, R, Yu, H, Tan, M.-H
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: cytochrome P450 1A2; glutathione; iron; messenger RNA; paracetamol; pazopanib; pyrimidine derivative; reactive oxygen metabolite; sulfonamide; antibody specificity; cell differentiation; drug effect; gene expression regulation; genetic transcription; genetics; human; induced pluripotent stem cell; liver cell; metabolism; oxidative stress; pathology; principal component analysis; toxic hepatitis; Acetaminophen; Cell Differentiation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Gene Expression Regulation; Glutathione; Hepatocytes; Humans; Induced Pluripotent Stem Cells; Iron; Organ Specificity; Oxidative Stress; Principal Component Analysis; Pyrimidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Transcription, Genetic
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173945
• Institution: National University of Singapore

10.1038/srep41238