Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity

10.1038/srep41238

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Main Authors:	Choudhury, Y, Toh, Y.C, Xing, J, Qu, Y, Poh, J, Huan, L, Tan, H.S, Kanesvaran, R, Yu, H, Tan, M.-H
Other Authors:	BIOENGINEERING
Format:	Article
Published:	2020
Subjects:	cytochrome P450 1A2 glutathione iron messenger RNA paracetamol pazopanib pyrimidine derivative reactive oxygen metabolite sulfonamide antibody specificity cell differentiation drug effect gene expression regulation genetic transcription genetics human induced pluripotent stem cell liver cell metabolism oxidative stress pathology principal component analysis toxic hepatitis Acetaminophen Cell Differentiation Chemical and Drug Induced Liver Injury Cytochrome P-450 CYP1A2 Gene Expression Regulation Glutathione Hepatocytes Humans Induced Pluripotent Stem Cells Iron Organ Specificity Oxidative Stress Principal Component Analysis Pyrimidines Reactive Oxygen Species RNA, Messenger Sulfonamides Transcription, Genetic
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173945
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1739452024-04-04T01:11:08Z Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Choudhury, Y Toh, Y.C Xing, J Qu, Y Poh, J Huan, L Tan, H.S Kanesvaran, R Yu, H Tan, M.-H BIOENGINEERING DUKE-NUS MEDICAL SCHOOL PHYSIOLOGY cytochrome P450 1A2 glutathione iron messenger RNA paracetamol pazopanib pyrimidine derivative reactive oxygen metabolite sulfonamide antibody specificity cell differentiation drug effect gene expression regulation genetic transcription genetics human induced pluripotent stem cell liver cell metabolism oxidative stress pathology principal component analysis toxic hepatitis Acetaminophen Cell Differentiation Chemical and Drug Induced Liver Injury Cytochrome P-450 CYP1A2 Gene Expression Regulation Glutathione Hepatocytes Humans Induced Pluripotent Stem Cells Iron Organ Specificity Oxidative Stress Principal Component Analysis Pyrimidines Reactive Oxygen Species RNA, Messenger Sulfonamides Transcription, Genetic 10.1038/srep41238 Scientific Reports 7 41238 2020-09-02T06:37:47Z 2020-09-02T06:37:47Z 2017 Article Choudhury, Y, Toh, Y.C, Xing, J, Qu, Y, Poh, J, Huan, L, Tan, H.S, Kanesvaran, R, Yu, H, Tan, M.-H (2017). Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Scientific Reports 7 : 41238. ScholarBank@NUS Repository. https://doi.org/10.1038/srep41238 20452322 https://scholarbank.nus.edu.sg/handle/10635/173945 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cytochrome P450 1A2 glutathione iron messenger RNA paracetamol pazopanib pyrimidine derivative reactive oxygen metabolite sulfonamide antibody specificity cell differentiation drug effect gene expression regulation genetic transcription genetics human induced pluripotent stem cell liver cell metabolism oxidative stress pathology principal component analysis toxic hepatitis Acetaminophen Cell Differentiation Chemical and Drug Induced Liver Injury Cytochrome P-450 CYP1A2 Gene Expression Regulation Glutathione Hepatocytes Humans Induced Pluripotent Stem Cells Iron Organ Specificity Oxidative Stress Principal Component Analysis Pyrimidines Reactive Oxygen Species RNA, Messenger Sulfonamides Transcription, Genetic
spellingShingle	cytochrome P450 1A2 glutathione iron messenger RNA paracetamol pazopanib pyrimidine derivative reactive oxygen metabolite sulfonamide antibody specificity cell differentiation drug effect gene expression regulation genetic transcription genetics human induced pluripotent stem cell liver cell metabolism oxidative stress pathology principal component analysis toxic hepatitis Acetaminophen Cell Differentiation Chemical and Drug Induced Liver Injury Cytochrome P-450 CYP1A2 Gene Expression Regulation Glutathione Hepatocytes Humans Induced Pluripotent Stem Cells Iron Organ Specificity Oxidative Stress Principal Component Analysis Pyrimidines Reactive Oxygen Species RNA, Messenger Sulfonamides Transcription, Genetic Choudhury, Y Toh, Y.C Xing, J Qu, Y Poh, J Huan, L Tan, H.S Kanesvaran, R Yu, H Tan, M.-H Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
description	10.1038/srep41238
author2	BIOENGINEERING
author_facet	BIOENGINEERING Choudhury, Y Toh, Y.C Xing, J Qu, Y Poh, J Huan, L Tan, H.S Kanesvaran, R Yu, H Tan, M.-H
format	Article
author	Choudhury, Y Toh, Y.C Xing, J Qu, Y Poh, J Huan, L Tan, H.S Kanesvaran, R Yu, H Tan, M.-H
author_sort	Choudhury, Y
title	Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
title_short	Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
title_full	Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
title_fullStr	Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
title_full_unstemmed	Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
title_sort	patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173945
_version_	1795374313264644096

Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity

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