Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

• Main Authors: Garcia-Miralles, M, Hong, X, Tan, L.J, Caron, N.S, Huang, Y, To, X.V, Lin, R.Y, Franciosi, S, Papapetropoulos, S, Hayardeny, L, Hayden, M.R, Chuang, K.-H, Pouladi, M.A
• Other Authors: DEAN'S OFFICE (MEDICINE)
• Format: Article
• Published: 2020
• Subjects: interleukin 6; laquinimod; quinolone derivative; animal; animal behavior; blood; corpus striatum; diffusion tensor imaging; disease model; dose response; drug effect; female; Huntington chorea; male; mouse; pathology; pathophysiology; white matter; Animals; Behavior, Animal; Corpus Striatum; Diffusion Tensor Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Huntington Disease; Interleukin-6; Male; Mice; Quinolones; White Matter
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173996
• Institution: National University of Singapore

10.1038/srep31652