Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration

• Main Authors: Xiang W., Cheong J.K., Ang S.H., Teo B., Xu P., Asari K., Sun W.T., Than H., Bunte R.M., Virshup D.M., Chuah C.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: beta catenin; casein kinase Ialpha; CD34 antigen; dasatinib; pyrvinium embonate; Wnt protein; adenosine triphosphate; antineoplastic agent; casein kinase I; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; cancer inhibition; cell renewal; chronic myeloid leukemia; colony formation; controlled study; human; human cell; mitochondrial respiration; mouse; nonhuman; protein protein interaction; signal transduction; stem cell; tumor xenograft; umbilical cord blood; animal; blast cell crisis; cancer transplantation; cell proliferation; chemistry; IC50; K-562 cell line; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; metabolism; mitochondrion; phosphorylation; RNA interference; SCID mouse; tumor cell line; Adenosine Triphosphate; Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; beta Catenin; Blast Crisis; Casein Kinase I; Cell Line, Tumor; Cell Proliferation; Dasatinib; Humans; Inhibitory Concentration 50; K562 Cells; Mice; Mice, SCID; Mitochondria; Neoplasm Transplantation; Phosphorylation; Pyrvinium Compounds; RNA Interference
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174134
• Institution: National University of Singapore

10.18632/oncotarget.5615