TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

• Main Authors: Ho, V, Lim, T.S, Lee, J, Steinberg, J, Szmyd, R, Tham, M, Yaligar, J, Kaldis, P, Abastado, J.-P, Chew, V
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: lysine stabilized polyinosinicpolycytidylic acid; mitogen activated protein kinase; protein kinase B; sorafenib; toll like receptor agonist; unclassified drug; antineoplastic agent; carbanilamide derivative; carboxymethylcellulose; carboxymethylcellulose polycytidylic polyinosinic acid polylysine; immunosuppressive agent; mitogen activated protein kinase kinase kinase; nicotinamide; polyinosinic polycytidylic acid; polylysine; TLR3 protein, human; toll like receptor 3; animal experiment; animal model; animal tissue; antiproliferative activity; Article; cancer inhibition; cell viability; controlled study; dendritic cell; drug cytotoxicity; drug efficacy; drug mechanism; drug response; enzyme phosphorylation; human; human cell; immune response; immunogenicity; in vitro study; in vivo study; liver cell carcinoma; lymphocyte activation; macrophage; male; mouse; natural killer cell; nonhuman; signal transduction; transposon; tumor microenvironment; agonists; analogs and derivatives; animal; apoptosis; C57BL mouse; CD8+ T lymphocyte; cell proliferation; cell survival; chemistry; cytology; disease course; immune system; liver tumor; metabolism; nonobese diabetic mouse; pathology; phosphorylation; SCID mouse; tumor cell line; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carboxymethylcellulose Sodium; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Humans; Immune System; Immunosuppressive Agents; Liver Neoplasms; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Niacinamide; Phenylurea Compounds; Phosphorylation; Poly I-C; Polylysine; Proto-Oncogene Proteins c-akt; Signal Transduction; Toll-Like Receptor 3
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174138
• Institution: National University of Singapore

10.18632/oncotarget.4583