TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

10.18632/oncotarget.4583

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Main Authors:	Ho, V, Lim, T.S, Lee, J, Steinberg, J, Szmyd, R, Tham, M, Yaligar, J, Kaldis, P, Abastado, J.-P, Chew, V
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	2020
Subjects:	lysine stabilized polyinosinicpolycytidylic acid mitogen activated protein kinase protein kinase B sorafenib toll like receptor agonist unclassified drug antineoplastic agent carbanilamide derivative carboxymethylcellulose carboxymethylcellulose polycytidylic polyinosinic acid polylysine immunosuppressive agent mitogen activated protein kinase kinase kinase nicotinamide polyinosinic polycytidylic acid polylysine TLR3 protein, human toll like receptor 3 animal experiment animal model animal tissue antiproliferative activity Article cancer inhibition cell viability controlled study dendritic cell drug cytotoxicity drug efficacy drug mechanism drug response enzyme phosphorylation human human cell immune response immunogenicity in vitro study in vivo study liver cell carcinoma lymphocyte activation macrophage male mouse natural killer cell nonhuman signal transduction transposon tumor microenvironment agonists analogs and derivatives animal apoptosis C57BL mouse CD8+ T lymphocyte cell proliferation cell survival chemistry cytology disease course immune system liver tumor metabolism nonobese diabetic mouse pathology phosphorylation SCID mouse tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Carboxymethylcellulose Sodium Carcinoma, Hepatocellular CD8-Positive T-Lymphocytes Cell Line, Tumor Cell Proliferation Cell Survival Disease Progression Extracellular Signal-Regulated MAP Kinases Humans Immune System Immunosuppressive Agents Liver Neoplasms Male MAP Kinase Kinase Kinases Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Niacinamide Phenylurea Compounds Phosphorylation Poly I-C Polylysine Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 3
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174138
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1741382024-04-22T03:33:28Z TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression Ho, V Lim, T.S Lee, J Steinberg, J Szmyd, R Tham, M Yaligar, J Kaldis, P Abastado, J.-P Chew, V BIOCHEMISTRY lysine stabilized polyinosinicpolycytidylic acid mitogen activated protein kinase protein kinase B sorafenib toll like receptor agonist unclassified drug antineoplastic agent carbanilamide derivative carboxymethylcellulose carboxymethylcellulose polycytidylic polyinosinic acid polylysine immunosuppressive agent mitogen activated protein kinase mitogen activated protein kinase kinase kinase nicotinamide polyinosinic polycytidylic acid polylysine protein kinase B sorafenib TLR3 protein, human toll like receptor 3 animal experiment animal model animal tissue antiproliferative activity Article cancer inhibition cell viability controlled study dendritic cell drug cytotoxicity drug efficacy drug mechanism drug response enzyme phosphorylation human human cell immune response immunogenicity in vitro study in vivo study liver cell carcinoma lymphocyte activation macrophage male mouse natural killer cell nonhuman signal transduction transposon tumor microenvironment agonists analogs and derivatives animal apoptosis C57BL mouse CD8+ T lymphocyte cell proliferation cell survival chemistry cytology disease course immune system liver cell carcinoma liver tumor metabolism nonobese diabetic mouse pathology phosphorylation SCID mouse tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Carboxymethylcellulose Sodium Carcinoma, Hepatocellular CD8-Positive T-Lymphocytes Cell Line, Tumor Cell Proliferation Cell Survival Disease Progression Extracellular Signal-Regulated MAP Kinases Humans Immune System Immunosuppressive Agents Liver Neoplasms Male MAP Kinase Kinase Kinases Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Niacinamide Phenylurea Compounds Phosphorylation Poly I-C Polylysine Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 3 10.18632/oncotarget.4583 Oncotarget 6 29 27252-27266 2020-09-03T10:36:58Z 2020-09-03T10:36:58Z 2015 Article Ho, V, Lim, T.S, Lee, J, Steinberg, J, Szmyd, R, Tham, M, Yaligar, J, Kaldis, P, Abastado, J.-P, Chew, V (2015). TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression. Oncotarget 6 (29) : 27252-27266. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4583 19492553 https://scholarbank.nus.edu.sg/handle/10635/174138 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	lysine stabilized polyinosinicpolycytidylic acid mitogen activated protein kinase protein kinase B sorafenib toll like receptor agonist unclassified drug antineoplastic agent carbanilamide derivative carboxymethylcellulose carboxymethylcellulose polycytidylic polyinosinic acid polylysine immunosuppressive agent mitogen activated protein kinase mitogen activated protein kinase kinase kinase nicotinamide polyinosinic polycytidylic acid polylysine protein kinase B sorafenib TLR3 protein, human toll like receptor 3 animal experiment animal model animal tissue antiproliferative activity Article cancer inhibition cell viability controlled study dendritic cell drug cytotoxicity drug efficacy drug mechanism drug response enzyme phosphorylation human human cell immune response immunogenicity in vitro study in vivo study liver cell carcinoma lymphocyte activation macrophage male mouse natural killer cell nonhuman signal transduction transposon tumor microenvironment agonists analogs and derivatives animal apoptosis C57BL mouse CD8+ T lymphocyte cell proliferation cell survival chemistry cytology disease course immune system liver cell carcinoma liver tumor metabolism nonobese diabetic mouse pathology phosphorylation SCID mouse tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Carboxymethylcellulose Sodium Carcinoma, Hepatocellular CD8-Positive T-Lymphocytes Cell Line, Tumor Cell Proliferation Cell Survival Disease Progression Extracellular Signal-Regulated MAP Kinases Humans Immune System Immunosuppressive Agents Liver Neoplasms Male MAP Kinase Kinase Kinases Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Niacinamide Phenylurea Compounds Phosphorylation Poly I-C Polylysine Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 3
spellingShingle	lysine stabilized polyinosinicpolycytidylic acid mitogen activated protein kinase protein kinase B sorafenib toll like receptor agonist unclassified drug antineoplastic agent carbanilamide derivative carboxymethylcellulose carboxymethylcellulose polycytidylic polyinosinic acid polylysine immunosuppressive agent mitogen activated protein kinase mitogen activated protein kinase kinase kinase nicotinamide polyinosinic polycytidylic acid polylysine protein kinase B sorafenib TLR3 protein, human toll like receptor 3 animal experiment animal model animal tissue antiproliferative activity Article cancer inhibition cell viability controlled study dendritic cell drug cytotoxicity drug efficacy drug mechanism drug response enzyme phosphorylation human human cell immune response immunogenicity in vitro study in vivo study liver cell carcinoma lymphocyte activation macrophage male mouse natural killer cell nonhuman signal transduction transposon tumor microenvironment agonists analogs and derivatives animal apoptosis C57BL mouse CD8+ T lymphocyte cell proliferation cell survival chemistry cytology disease course immune system liver cell carcinoma liver tumor metabolism nonobese diabetic mouse pathology phosphorylation SCID mouse tumor cell line Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Carboxymethylcellulose Sodium Carcinoma, Hepatocellular CD8-Positive T-Lymphocytes Cell Line, Tumor Cell Proliferation Cell Survival Disease Progression Extracellular Signal-Regulated MAP Kinases Humans Immune System Immunosuppressive Agents Liver Neoplasms Male MAP Kinase Kinase Kinases Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Niacinamide Phenylurea Compounds Phosphorylation Poly I-C Polylysine Proto-Oncogene Proteins c-akt Signal Transduction Toll-Like Receptor 3 Ho, V Lim, T.S Lee, J Steinberg, J Szmyd, R Tham, M Yaligar, J Kaldis, P Abastado, J.-P Chew, V TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
description	10.18632/oncotarget.4583
author2	BIOCHEMISTRY
author_facet	BIOCHEMISTRY Ho, V Lim, T.S Lee, J Steinberg, J Szmyd, R Tham, M Yaligar, J Kaldis, P Abastado, J.-P Chew, V
format	Article
author	Ho, V Lim, T.S Lee, J Steinberg, J Szmyd, R Tham, M Yaligar, J Kaldis, P Abastado, J.-P Chew, V
author_sort	Ho, V
title	TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
title_short	TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
title_full	TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
title_fullStr	TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
title_full_unstemmed	TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
title_sort	tlr3 agonist and sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174138
_version_	1800914218229170176

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

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