Cystathionine ?-synthase inhibition is a potential therapeutic approach to treatment of ischemic injury

• Main Authors: Chan, S.J, Chai, C, Lim, T.W, Yamamoto, M, Lo, E.H, Lai, M.K.P, Wong, P.T.H
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: cystathionine beta synthase; cysteine; homocysteine; hydrogen sulfide; neuron specific nuclear protein; aminooxyacetic acid; enzyme inhibitor; glucose; animal cell; animal experiment; animal model; animal tissue; Article; astrocyte; cell death; cell viability; controlled study; human; human cell; hypoxic ischemic encephalopathy; immunofluorescence test; male; MTT assay; nonhuman; protein expression; protein localization; rat; upregulation; Western blotting; animal; antagonists and inhibitors; brain; brain ischemia; cell culture; cell hypoxia; cell survival; cerebral artery disease; deficiency; disease model; drug effects; genetics; metabolism; pathology; PC12 cell line; physiology; Sprague Dawley rat; tumor cell line; Aminooxyacetic Acid; Animals; Astrocytes; Brain; Brain Ischemia; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cystathionine beta-Synthase; Disease Models, Animal; Enzyme Inhibitors; Glucose; Humans; Hydrogen Sulfide; Infarction, Middle Cerebral Artery; PC12 Cells; Rats; Rats, Sprague-Dawley
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174141
• Institution: National University of Singapore

10.1177/1759091415578711