Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

• Main Authors: Her, Z, Teng, T.-S, Tan, J.J.L, Teo, T.-H, Kam, Y.-W, Lum, F.-M, Lee, W.W.L, Gabriel, C, Melchiotti, R, Andiappan, A.K, Lulla, V, Lulla, A, Win, M.K, Chow, A, Biswas, S.K, Leo, Y.-S, Lecuit, M, Merits, A, Rénia, L, Ng, L.F.P
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: 2020
• Subjects: glycoprotein E2; neutralizing antibody; toll like receptor 3; TLR3 protein, human; TLR3 protein, mouse; virus antibody; adult; aged; animal cell; animal experiment; animal model; antibody response; arthritis; Article; bone marrow cell; cell infiltration; chikungunya; Chikungunya alphavirus; controlled study; disease severity; female; fibroblast; genotype; hematopoietic cell; human; human cell; infection sensitivity; innate immunity; major clinical study; male; mouse; nonhuman; priority journal; protein expression; signal transduction; single nucleotide polymorphism; viral clearance; virus load; virus replication; animal; C57BL mouse; Chikungunya virus; genetics; immunology; knockout mouse; middle aged; pathology; physiology; species difference; virology; young adult; Adult; Aged; Animals; Antibodies, Neutralizing; Antibodies, Viral; Chikungunya Fever; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Polymorphism, Single Nucleotide; Species Specificity; Toll-Like Receptor 3; Virus Replication; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174149
• Institution: National University of Singapore

10.15252/emmm.201404459