Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

10.18632/oncotarget.2881

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Bibliographic Details
Main Authors:	Li F., Shanmugam M.K., Siveen K.S., Wang F., Ong T.H., Loo S.Y., Swamy M.M.M., Mandal S., Kumar A.P., Goh B.C., Kundu T., Ahn K.S., Wang L.Z., Hui K.M., Sethi G.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	antineoplastic agent benzophenone derivative cisplatin cyclin D1 garcinol immunoglobulin enhancer binding protein Ki 67 antigen protein bcl 2 survivin tumor marker unclassified drug vasculotropin biological marker messenger RNA plant extract terpene animal cell animal experiment animal model animal tissue apoptosis area under the curve Article cancer combination chemotherapy cancer inhibition cancer model capillary density carcinoma cell cell viability chemosensitization controlled study down regulation drug absorption drug blood level drug exposure drug potentiation female gene expression regulation gene product head and neck carcinoma histopathology human human cell in vivo study maximum plasma concentration monotherapy mouse nonhuman systemic therapy transcription initiation tumor xenograft \garcinol animal Carcinoma, Squamous Cell cell proliferation drug effects drug screening enzyme immunoassay genetics Head and Neck Neoplasms metabolism nude mouse pathology real time polymerase chain reaction reverse transcription polymerase chain reaction signal transduction tumor cell culture Western blotting Animals Antineoplastic Agents Apoptosis Biomarkers Blotting, Western Cell Proliferation Cisplatin Down-Regulation Drug Synergism Female Humans Immunoenzyme Techniques Mice Mice, Nude Plant Extracts Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Signal Transduction Terpenes Tumor Cells, Cultured Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174150
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Institution:	National University of Singapore

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Summary:	10.18632/oncotarget.2881