Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

10.18632/oncotarget.2881

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Main Authors:	Li F., Shanmugam M.K., Siveen K.S., Wang F., Ong T.H., Loo S.Y., Swamy M.M.M., Mandal S., Kumar A.P., Goh B.C., Kundu T., Ahn K.S., Wang L.Z., Hui K.M., Sethi G.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	antineoplastic agent benzophenone derivative cisplatin cyclin D1 garcinol immunoglobulin enhancer binding protein Ki 67 antigen protein bcl 2 survivin tumor marker unclassified drug vasculotropin biological marker messenger RNA plant extract terpene animal cell animal experiment animal model animal tissue apoptosis area under the curve Article cancer combination chemotherapy cancer inhibition cancer model capillary density carcinoma cell cell viability chemosensitization controlled study down regulation drug absorption drug blood level drug exposure drug potentiation female gene expression regulation gene product head and neck carcinoma histopathology human human cell in vivo study maximum plasma concentration monotherapy mouse nonhuman systemic therapy transcription initiation tumor xenograft \garcinol animal Carcinoma, Squamous Cell cell proliferation drug effects drug screening enzyme immunoassay genetics Head and Neck Neoplasms metabolism nude mouse pathology real time polymerase chain reaction reverse transcription polymerase chain reaction signal transduction tumor cell culture Western blotting Animals Antineoplastic Agents Apoptosis Biomarkers Blotting, Western Cell Proliferation Cisplatin Down-Regulation Drug Synergism Female Humans Immunoenzyme Techniques Mice Mice, Nude Plant Extracts Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Signal Transduction Terpenes Tumor Cells, Cultured Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174150
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1741502024-04-05T09:04:02Z Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers Li F. Shanmugam M.K. Siveen K.S. Wang F. Ong T.H. Loo S.Y. Swamy M.M.M. Mandal S. Kumar A.P. Goh B.C. Kundu T. Ahn K.S. Wang L.Z. Hui K.M. Sethi G. CANCER SCIENCE INSTITUTE OF SINGAPORE PHARMACOLOGY MECHANOBIOLOGY INSTITUTE PHYSIOLOGY PHARMACY DUKE-NUS MEDICAL SCHOOL antineoplastic agent benzophenone derivative cisplatin cyclin D1 garcinol immunoglobulin enhancer binding protein Ki 67 antigen protein bcl 2 survivin tumor marker unclassified drug vasculotropin antineoplastic agent biological marker cisplatin garcinol messenger RNA plant extract terpene animal cell animal experiment animal model animal tissue apoptosis area under the curve Article cancer combination chemotherapy cancer inhibition cancer model capillary density carcinoma cell cell viability chemosensitization controlled study down regulation drug absorption drug blood level drug exposure drug potentiation female gene expression regulation gene product head and neck carcinoma histopathology human human cell in vivo study maximum plasma concentration monotherapy mouse nonhuman systemic therapy transcription initiation tumor xenograft \garcinol animal Carcinoma, Squamous Cell cell proliferation down regulation drug effects drug potentiation drug screening enzyme immunoassay genetics Head and Neck Neoplasms metabolism nude mouse pathology real time polymerase chain reaction reverse transcription polymerase chain reaction signal transduction tumor cell culture Western blotting Animals Antineoplastic Agents Apoptosis Biomarkers Blotting, Western Carcinoma, Squamous Cell Cell Proliferation Cisplatin Down-Regulation Drug Synergism Female Head and Neck Neoplasms Humans Immunoenzyme Techniques Mice Mice, Nude Plant Extracts Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Signal Transduction Terpenes Tumor Cells, Cultured Xenograft Model Antitumor Assays 10.18632/oncotarget.2881 Oncotarget 6 7 5147-5163 2020-09-03T10:39:15Z 2020-09-03T10:39:15Z 2015 Article Li F., Shanmugam M.K., Siveen K.S., Wang F., Ong T.H., Loo S.Y., Swamy M.M.M., Mandal S., Kumar A.P., Goh B.C., Kundu T., Ahn K.S., Wang L.Z., Hui K.M., Sethi G. (2015). Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. Oncotarget 6 (7) : 5147-5163. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.2881 19492553 https://scholarbank.nus.edu.sg/handle/10635/174150 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antineoplastic agent benzophenone derivative cisplatin cyclin D1 garcinol immunoglobulin enhancer binding protein Ki 67 antigen protein bcl 2 survivin tumor marker unclassified drug vasculotropin antineoplastic agent biological marker cisplatin garcinol messenger RNA plant extract terpene animal cell animal experiment animal model animal tissue apoptosis area under the curve Article cancer combination chemotherapy cancer inhibition cancer model capillary density carcinoma cell cell viability chemosensitization controlled study down regulation drug absorption drug blood level drug exposure drug potentiation female gene expression regulation gene product head and neck carcinoma histopathology human human cell in vivo study maximum plasma concentration monotherapy mouse nonhuman systemic therapy transcription initiation tumor xenograft \garcinol animal Carcinoma, Squamous Cell cell proliferation down regulation drug effects drug potentiation drug screening enzyme immunoassay genetics Head and Neck Neoplasms metabolism nude mouse pathology real time polymerase chain reaction reverse transcription polymerase chain reaction signal transduction tumor cell culture Western blotting Animals Antineoplastic Agents Apoptosis Biomarkers Blotting, Western Carcinoma, Squamous Cell Cell Proliferation Cisplatin Down-Regulation Drug Synergism Female Head and Neck Neoplasms Humans Immunoenzyme Techniques Mice Mice, Nude Plant Extracts Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Signal Transduction Terpenes Tumor Cells, Cultured Xenograft Model Antitumor Assays
spellingShingle	antineoplastic agent benzophenone derivative cisplatin cyclin D1 garcinol immunoglobulin enhancer binding protein Ki 67 antigen protein bcl 2 survivin tumor marker unclassified drug vasculotropin antineoplastic agent biological marker cisplatin garcinol messenger RNA plant extract terpene animal cell animal experiment animal model animal tissue apoptosis area under the curve Article cancer combination chemotherapy cancer inhibition cancer model capillary density carcinoma cell cell viability chemosensitization controlled study down regulation drug absorption drug blood level drug exposure drug potentiation female gene expression regulation gene product head and neck carcinoma histopathology human human cell in vivo study maximum plasma concentration monotherapy mouse nonhuman systemic therapy transcription initiation tumor xenograft \garcinol animal Carcinoma, Squamous Cell cell proliferation down regulation drug effects drug potentiation drug screening enzyme immunoassay genetics Head and Neck Neoplasms metabolism nude mouse pathology real time polymerase chain reaction reverse transcription polymerase chain reaction signal transduction tumor cell culture Western blotting Animals Antineoplastic Agents Apoptosis Biomarkers Blotting, Western Carcinoma, Squamous Cell Cell Proliferation Cisplatin Down-Regulation Drug Synergism Female Head and Neck Neoplasms Humans Immunoenzyme Techniques Mice Mice, Nude Plant Extracts Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Signal Transduction Terpenes Tumor Cells, Cultured Xenograft Model Antitumor Assays Li F. Shanmugam M.K. Siveen K.S. Wang F. Ong T.H. Loo S.Y. Swamy M.M.M. Mandal S. Kumar A.P. Goh B.C. Kundu T. Ahn K.S. Wang L.Z. Hui K.M. Sethi G. Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
description	10.18632/oncotarget.2881
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Li F. Shanmugam M.K. Siveen K.S. Wang F. Ong T.H. Loo S.Y. Swamy M.M.M. Mandal S. Kumar A.P. Goh B.C. Kundu T. Ahn K.S. Wang L.Z. Hui K.M. Sethi G.
format	Article
author	Li F. Shanmugam M.K. Siveen K.S. Wang F. Ong T.H. Loo S.Y. Swamy M.M.M. Mandal S. Kumar A.P. Goh B.C. Kundu T. Ahn K.S. Wang L.Z. Hui K.M. Sethi G.
author_sort	Li F.
title	Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
title_short	Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
title_full	Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
title_fullStr	Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
title_full_unstemmed	Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
title_sort	garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174150
_version_	1800914219246288896

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

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