SPHK1 regulates proliferation and survival responses in triplenegative breast cancer

• Main Authors: Datta, A, Loo, S.Y, Huang, B, Wong, L, Tan, S.S.L, Tan, T.Z, Lee, S.-C, Thiery, J.P, Lim, Y.C, Yong, W.P, Lam, Y, Kumar, A.P, Yap, C.T
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: 2,2 dimethyl(1 oxo 2 hexadecyn 1 yl) 1,1 dimethylethyl ester 3 oxazolidinecarboxylic acid; docetaxel; doxorubicin; fluorouracil; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphotransferase inhibitor; protein kinase B; ski 5c; small interfering RNA; sphingosine kinase 1; unclassified drug; phosphotransferase; sphingosine kinase; animal experiment; animal model; article; cancer growth; cancer prognosis; cancer survival; controlled study; drug sensitization; enzyme inhibition; female; gene silencing; human; human cell; human tissue; in vitro study; mouse; multiple cycle treatment; nonhuman; phase 2 clinical trial (topic); regulatory mechanism; signal transduction; triple negative breast cancer; animal; cell proliferation; cell survival; enzymology; genetic transfection; genetics; MCF 7 cell line; metabolism; pathology; physiology; SCID mouse; tumor cell line; xenograft; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Heterografts; Humans; MCF-7 Cells; Mice; Mice, SCID; Phosphotransferases (Alcohol Group Acceptor); Transfection; Triple Negative Breast Neoplasms
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174167
• Institution: National University of Singapore

10.18632/oncotarget.1874