Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1

10.1038/s41467-018-05644-0

Saved in:

Bibliographic Details
Main Authors:	Xu, X, Li, Y, Bharath, S.R, Ozturk, M.B, Bowler, M.W, Loo, B.Z.L, Tergaonkar, V, Song, H
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	DNA fragment immunoglobulin enhancer binding protein protein p52 transcription factor Ets 1 disulfide DNA ETS1 protein, human protein binding telomerase TERT protein, human cancer chemical binding complexity crystal structure inhibition mutation reactivation Article binding affinity DNA binding ETS domain gene activation HEK293T cell line human human cell immunoprecipitation multiple cancer promoter region protein protein interaction signal transduction TERT gene transactivation binding site chemistry enzyme activation Escherichia coli genetics HEK293 cell line metabolism protein multimerization X ray crystallography Binding Sites Crystallography, X-Ray Disulfides Enzyme Activation HEK293 Cells Humans NF-kappa B NF-kappa B p52 Subunit Promoter Regions, Genetic Protein Binding Protein Multimerization Proto-Oncogene Protein c-ets-1 Signal Transduction Telomerase
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174210
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

id	sg-nus-scholar.10635-174210
record_format	dspace
spelling	sg-nus-scholar.10635-1742102024-04-22T03:11:05Z Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1 Xu, X Li, Y Bharath, S.R Ozturk, M.B Bowler, M.W Loo, B.Z.L Tergaonkar, V Song, H BIOCHEMISTRY DNA fragment immunoglobulin enhancer binding protein protein p52 transcription factor Ets 1 disulfide DNA ETS1 protein, human immunoglobulin enhancer binding protein protein binding telomerase TERT protein, human transcription factor Ets 1 cancer chemical binding complexity crystal structure DNA inhibition mutation reactivation Article binding affinity crystal structure DNA binding ETS domain gene activation HEK293T cell line human human cell immunoprecipitation multiple cancer promoter region protein protein interaction signal transduction TERT gene transactivation binding site chemistry enzyme activation Escherichia coli genetics HEK293 cell line metabolism protein multimerization X ray crystallography Binding Sites Crystallography, X-Ray Disulfides DNA Enzyme Activation Escherichia coli HEK293 Cells Humans NF-kappa B NF-kappa B p52 Subunit Promoter Regions, Genetic Protein Binding Protein Multimerization Proto-Oncogene Protein c-ets-1 Signal Transduction Telomerase 10.1038/s41467-018-05644-0 Nature Communications 9 1 3183 2020-09-04T01:46:49Z 2020-09-04T01:46:49Z 2018 Article Xu, X, Li, Y, Bharath, S.R, Ozturk, M.B, Bowler, M.W, Loo, B.Z.L, Tergaonkar, V, Song, H (2018). Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1. Nature Communications 9 (1) : 3183. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-05644-0 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/174210 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	DNA fragment immunoglobulin enhancer binding protein protein p52 transcription factor Ets 1 disulfide DNA ETS1 protein, human immunoglobulin enhancer binding protein protein binding telomerase TERT protein, human transcription factor Ets 1 cancer chemical binding complexity crystal structure DNA inhibition mutation reactivation Article binding affinity crystal structure DNA binding ETS domain gene activation HEK293T cell line human human cell immunoprecipitation multiple cancer promoter region protein protein interaction signal transduction TERT gene transactivation binding site chemistry enzyme activation Escherichia coli genetics HEK293 cell line metabolism protein multimerization X ray crystallography Binding Sites Crystallography, X-Ray Disulfides DNA Enzyme Activation Escherichia coli HEK293 Cells Humans NF-kappa B NF-kappa B p52 Subunit Promoter Regions, Genetic Protein Binding Protein Multimerization Proto-Oncogene Protein c-ets-1 Signal Transduction Telomerase
spellingShingle	DNA fragment immunoglobulin enhancer binding protein protein p52 transcription factor Ets 1 disulfide DNA ETS1 protein, human immunoglobulin enhancer binding protein protein binding telomerase TERT protein, human transcription factor Ets 1 cancer chemical binding complexity crystal structure DNA inhibition mutation reactivation Article binding affinity crystal structure DNA binding ETS domain gene activation HEK293T cell line human human cell immunoprecipitation multiple cancer promoter region protein protein interaction signal transduction TERT gene transactivation binding site chemistry enzyme activation Escherichia coli genetics HEK293 cell line metabolism protein multimerization X ray crystallography Binding Sites Crystallography, X-Ray Disulfides DNA Enzyme Activation Escherichia coli HEK293 Cells Humans NF-kappa B NF-kappa B p52 Subunit Promoter Regions, Genetic Protein Binding Protein Multimerization Proto-Oncogene Protein c-ets-1 Signal Transduction Telomerase Xu, X Li, Y Bharath, S.R Ozturk, M.B Bowler, M.W Loo, B.Z.L Tergaonkar, V Song, H Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
description	10.1038/s41467-018-05644-0
author2	BIOCHEMISTRY
author_facet	BIOCHEMISTRY Xu, X Li, Y Bharath, S.R Ozturk, M.B Bowler, M.W Loo, B.Z.L Tergaonkar, V Song, H
format	Article
author	Xu, X Li, Y Bharath, S.R Ozturk, M.B Bowler, M.W Loo, B.Z.L Tergaonkar, V Song, H
author_sort	Xu, X
title	Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
title_short	Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
title_full	Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
title_fullStr	Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
title_full_unstemmed	Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
title_sort	structural basis for reactivating the mutant tert promoter by cooperative binding of p52 and ets1
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174210
_version_	1800914223407038464

Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1

Similar Items