A systematic approach to the development of a safe live attenuated Zika vaccine

• Main Authors: Kwek, S.S, Watanabe, S, Chan, K.R, Ong, E.Z, Tan, H.C, Ng, W.C, Nguyen, M.T.X, Gan, E.S, Zhang, S.L, Chan, K.W.K, Tan, J.H, Sessions, O.M, Manuel, M, Pompon, J, Chua, C, Hazirah, S, Tryggvason, K, Vasudevan, S.G, Ooi, E.E
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: interferon regulatory factor 3; live vaccine; Zika virus vaccine; virus vaccine; cell; immunity; rodent; strategic approach; vaccine; vertical transmission; yellow fever; Zika virus disease; adult; animal cell; animal experiment; animal model; animal tissue; Article; B lymphocyte; controlled study; dendritic cell; drug efficacy; drug mechanism; drug safety; embryo; female; fetus; gene activation; genetic variability; genomic instability; human; human cell; in vitro propagation; infection risk; innate immunity; male; mouse; mouse model; next generation sequencing; nonhuman; single nucleotide polymorphism; T lymphocyte; umbilical vein endothelial cell; vaccine immunogenicity; Vero cell line; virus culture; virus mutation; virus plaque; virus transmission; whole genome sequencing; wild type; Zika fever; Zika virus; Aedes; animal; evaluation study; genetics; growth, development and aging; immunological technique; immunology; virology; Flavivirus; Human immunodeficiency virus 1; Animals; Dendritic Cells; Humans; Immunologic Techniques; Mice; Vaccines, Attenuated; Viral Vaccines; Zika Virus; Zika Virus Infection
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174234
• Institution: National University of Singapore

10.1038/s41467-018-03337-2