A systematic approach to the development of a safe live attenuated Zika vaccine

10.1038/s41467-018-03337-2

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Main Authors:	Kwek, S.S, Watanabe, S, Chan, K.R, Ong, E.Z, Tan, H.C, Ng, W.C, Nguyen, M.T.X, Gan, E.S, Zhang, S.L, Chan, K.W.K, Tan, J.H, Sessions, O.M, Manuel, M, Pompon, J, Chua, C, Hazirah, S, Tryggvason, K, Vasudevan, S.G, Ooi, E.E
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	interferon regulatory factor 3 live vaccine Zika virus vaccine virus vaccine cell immunity rodent strategic approach vaccine vertical transmission yellow fever Zika virus disease adult animal cell animal experiment animal model animal tissue Article B lymphocyte controlled study dendritic cell drug efficacy drug mechanism drug safety embryo female fetus gene activation genetic variability genomic instability human human cell in vitro propagation infection risk innate immunity male mouse mouse model next generation sequencing nonhuman single nucleotide polymorphism T lymphocyte umbilical vein endothelial cell vaccine immunogenicity Vero cell line virus culture virus mutation virus plaque virus transmission whole genome sequencing wild type Zika fever Zika virus Aedes animal evaluation study genetics growth, development and aging immunological technique immunology virology Flavivirus Human immunodeficiency virus 1 Animals Dendritic Cells Humans Immunologic Techniques Mice Vaccines, Attenuated Viral Vaccines Zika Virus Zika Virus Infection
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174234
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1742342020-09-06T15:54:05Z A systematic approach to the development of a safe live attenuated Zika vaccine Kwek, S.S Watanabe, S Chan, K.R Ong, E.Z Tan, H.C Ng, W.C Nguyen, M.T.X Gan, E.S Zhang, S.L Chan, K.W.K Tan, J.H Sessions, O.M Manuel, M Pompon, J Chua, C Hazirah, S Tryggvason, K Vasudevan, S.G Ooi, E.E DUKE-NUS MEDICAL SCHOOL interferon regulatory factor 3 live vaccine Zika virus vaccine live vaccine virus vaccine cell immunity rodent strategic approach vaccine vertical transmission yellow fever Zika virus disease adult animal cell animal experiment animal model animal tissue Article B lymphocyte controlled study dendritic cell drug efficacy drug mechanism drug safety embryo female fetus gene activation genetic variability genomic instability human human cell in vitro propagation infection risk innate immunity male mouse mouse model next generation sequencing nonhuman single nucleotide polymorphism T lymphocyte umbilical vein endothelial cell vaccine immunogenicity Vero cell line vertical transmission virus culture virus mutation virus plaque virus transmission whole genome sequencing wild type Zika fever Zika virus Aedes animal evaluation study genetics growth, development and aging immunological technique immunology virology Zika fever Flavivirus Human immunodeficiency virus 1 Zika virus Aedes Animals Dendritic Cells Humans Immunologic Techniques Mice Vaccines, Attenuated Viral Vaccines Zika Virus Zika Virus Infection 10.1038/s41467-018-03337-2 Nature Communications 9 1 1031 2020-09-04T01:51:39Z 2020-09-04T01:51:39Z 2018 Article Kwek, S.S, Watanabe, S, Chan, K.R, Ong, E.Z, Tan, H.C, Ng, W.C, Nguyen, M.T.X, Gan, E.S, Zhang, S.L, Chan, K.W.K, Tan, J.H, Sessions, O.M, Manuel, M, Pompon, J, Chua, C, Hazirah, S, Tryggvason, K, Vasudevan, S.G, Ooi, E.E (2018). A systematic approach to the development of a safe live attenuated Zika vaccine. Nature Communications 9 (1) : 1031. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-03337-2 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/174234 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
country	Singapore
collection	ScholarBank@NUS
topic	interferon regulatory factor 3 live vaccine Zika virus vaccine live vaccine virus vaccine cell immunity rodent strategic approach vaccine vertical transmission yellow fever Zika virus disease adult animal cell animal experiment animal model animal tissue Article B lymphocyte controlled study dendritic cell drug efficacy drug mechanism drug safety embryo female fetus gene activation genetic variability genomic instability human human cell in vitro propagation infection risk innate immunity male mouse mouse model next generation sequencing nonhuman single nucleotide polymorphism T lymphocyte umbilical vein endothelial cell vaccine immunogenicity Vero cell line vertical transmission virus culture virus mutation virus plaque virus transmission whole genome sequencing wild type Zika fever Zika virus Aedes animal evaluation study genetics growth, development and aging immunological technique immunology virology Zika fever Flavivirus Human immunodeficiency virus 1 Zika virus Aedes Animals Dendritic Cells Humans Immunologic Techniques Mice Vaccines, Attenuated Viral Vaccines Zika Virus Zika Virus Infection
spellingShingle	interferon regulatory factor 3 live vaccine Zika virus vaccine live vaccine virus vaccine cell immunity rodent strategic approach vaccine vertical transmission yellow fever Zika virus disease adult animal cell animal experiment animal model animal tissue Article B lymphocyte controlled study dendritic cell drug efficacy drug mechanism drug safety embryo female fetus gene activation genetic variability genomic instability human human cell in vitro propagation infection risk innate immunity male mouse mouse model next generation sequencing nonhuman single nucleotide polymorphism T lymphocyte umbilical vein endothelial cell vaccine immunogenicity Vero cell line vertical transmission virus culture virus mutation virus plaque virus transmission whole genome sequencing wild type Zika fever Zika virus Aedes animal evaluation study genetics growth, development and aging immunological technique immunology virology Zika fever Flavivirus Human immunodeficiency virus 1 Zika virus Aedes Animals Dendritic Cells Humans Immunologic Techniques Mice Vaccines, Attenuated Viral Vaccines Zika Virus Zika Virus Infection Kwek, S.S Watanabe, S Chan, K.R Ong, E.Z Tan, H.C Ng, W.C Nguyen, M.T.X Gan, E.S Zhang, S.L Chan, K.W.K Tan, J.H Sessions, O.M Manuel, M Pompon, J Chua, C Hazirah, S Tryggvason, K Vasudevan, S.G Ooi, E.E A systematic approach to the development of a safe live attenuated Zika vaccine
description	10.1038/s41467-018-03337-2
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Kwek, S.S Watanabe, S Chan, K.R Ong, E.Z Tan, H.C Ng, W.C Nguyen, M.T.X Gan, E.S Zhang, S.L Chan, K.W.K Tan, J.H Sessions, O.M Manuel, M Pompon, J Chua, C Hazirah, S Tryggvason, K Vasudevan, S.G Ooi, E.E
format	Article
author	Kwek, S.S Watanabe, S Chan, K.R Ong, E.Z Tan, H.C Ng, W.C Nguyen, M.T.X Gan, E.S Zhang, S.L Chan, K.W.K Tan, J.H Sessions, O.M Manuel, M Pompon, J Chua, C Hazirah, S Tryggvason, K Vasudevan, S.G Ooi, E.E
author_sort	Kwek, S.S
title	A systematic approach to the development of a safe live attenuated Zika vaccine
title_short	A systematic approach to the development of a safe live attenuated Zika vaccine
title_full	A systematic approach to the development of a safe live attenuated Zika vaccine
title_fullStr	A systematic approach to the development of a safe live attenuated Zika vaccine
title_full_unstemmed	A systematic approach to the development of a safe live attenuated Zika vaccine
title_sort	systematic approach to the development of a safe live attenuated zika vaccine
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174234
_version_	1681101719725932544

A systematic approach to the development of a safe live attenuated Zika vaccine

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