Large-scale production of foot-and-mouth disease virus (serotype Asia1) VLP vaccine in Escherichia coli and protection potency evaluation in cattle

• Main Authors: Xiao, Y, Chen, H.-Y, Wang, Y, Yin, B, Lv, C, Mo, X, Yan, H, Xuan, Y, Huang, Y, Pang, W, Li, X, Yuan, Y.A, Tian, K.
• Other Authors: BIOLOGY (NU)
• Format: Article
• Published: BioMed Central Ltd. 2020
• Subjects: Antibodies; Escherichia coli; Purification; Vaccines; Viruses; E. coli; Fifty percent protection dose (PD50); Foot and mouth disease; Serotypes; Virus-like particles; Diseases; capsid protein; foot and mouth disease vaccine; immunological adjuvant; neutralizing antibody; protein VP0; protein VP1; protein VP3; unclassified drug; virus like particle vaccine; recombinant protein; animal experiment; antibody response; antibody specificity; Article; bovine; chromatography; controlled study; drug potency; enzyme linked immunosorbent assay; fermentation; foot and mouth disease; Foot and mouth disease virus; gene expression system; nonhuman; protein assembly; protein purification; serotype; single drug dose; vaccination; animal; batch cell culture; biosynthesis; Cattle Diseases; Foot-and-Mouth Disease; genetics; metabolism; procedures; protein engineering; virology; Animals; Batch Cell Culture Techniques; Cattle; Protein Engineering; Recombinant Proteins; Vaccines, Virus-Like Particle
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174251
• Institution: National University of Singapore

10.1186/s12896-016-0285-6