HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

• Main Authors: Yan, T, Ooi, W.F, Qamra, A, Cheung, A, Ma, D, Sundaram, G.M, Xu, C, Xing, M, Poon, L, Wang, J, Loh, Y.P, Ho, J.H.J, Ng, J.J.Q, Ramlee, M.K, Aswad, L, Rozen, S.G, Ghosh, S, Bard, F.A, Sampath, P, Tergaonkar, V, Davies, J.O.J, Hughes, J.R, Goh, E, Bi, X, Fullwood, M.J, Tan, P, Li, S
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Published: Nature Publishing Group 2020
• Subjects: microRNA; microRNA 615 3p; unclassified drug; homeodomain protein; HOXC5 protein, human; MIRN615 microRNA, human; telomerase; TERT protein, human; aging; cancer; cell; differentiation; embryonic development; gene expression; genome; inhibition; physiology; primate; tumor; 3' untranslated region; 5' untranslated region; Article; carcinogenesis; cell differentiation; enhancer region; gene; hoxc5 gene; human; human cell; intron; reverse transcription polymerase chain reaction; animal; biosynthesis; cell transformation; genetics; HEK293 cell line; HeLa cell line; Hep-G2 cell line; MCF-7 cell line; mouse; neoplasm; pathology; promoter region; tumor cell line; Mammalia; Primates; 3' Untranslated Regions; 5' Untranslated Regions; Animals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Enhancer Elements, Genetic; HEK293 Cells; HeLa Cells; Hep G2 Cells; Homeodomain Proteins; Humans; MCF-7 Cells; Mice; MicroRNAs; Neoplasms; Promoter Regions, Genetic; Telomerase
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174312
• Institution: National University of Singapore

10.1038/s41467-017-02601-1