Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

• Main Authors: Lum, F.-M, Couderc, T, Chia, B.-S, Ong, R.-Y, Her, Z, Chow, A, Leo, Y.-S, Kam, Y.-W, Rénia, L, Lecuit, M, Ng, L.F.P
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: Fc receptor; Fc receptor IIa; gamma interferon; neutralizing antibody; virus antibody; animal; arthralgia; C57BL mouse; cell culture; chikungunya; Chikungunya virus; human; immunology; knockout mouse; macrophage; metabolism; mouse; pathology; physiology; severity of illness index; virology; virus load; virus replication; Animals; Antibodies, Neutralizing; Antibodies, Viral; Arthralgia; Cells, Cultured; Chikungunya Fever; Humans; Interferon-gamma; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, IgG; Severity of Illness Index; Viral Load; Virus Replication
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174342
• Institution: National University of Singapore

10.1038/s41598-018-20305-4