Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations

10.1038/s41598-017-15930-4

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Main Authors:	Yadahalli, S, Li, J, Lane, D.P, Gosavi, S, Verma, C.S
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	MDM2 protein, human peptide protein binding protein MDM2 protein p53 TP53 protein, human binding site chemistry genetics human molecular dynamics mutation protein conformation protein secondary structure thermodynamics X ray crystallography Binding Sites Crystallography, X-Ray Humans Molecular Dynamics Simulation Mutation Peptides Protein Binding Protein Conformation Protein Structure, Secondary Proto-Oncogene Proteins c-mdm2 Thermodynamics Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174385
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1743852024-04-24T05:48:36Z Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations Yadahalli, S Li, J Lane, D.P Gosavi, S Verma, C.S DUKE-NUS MEDICAL SCHOOL MEDICINE BIOLOGY (NU) MDM2 protein, human peptide protein binding protein MDM2 protein p53 TP53 protein, human binding site chemistry genetics human molecular dynamics mutation protein conformation protein secondary structure thermodynamics X ray crystallography Binding Sites Crystallography, X-Ray Humans Molecular Dynamics Simulation Mutation Peptides Protein Binding Protein Conformation Protein Structure, Secondary Proto-Oncogene Proteins c-mdm2 Thermodynamics Tumor Suppressor Protein p53 10.1038/s41598-017-15930-4 Scientific Reports 7 1 15600 2020-09-04T03:30:38Z 2020-09-04T03:30:38Z 2017 Article Yadahalli, S, Li, J, Lane, D.P, Gosavi, S, Verma, C.S (2017). Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations. Scientific Reports 7 (1) : 15600. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-15930-4 2045-2322 https://scholarbank.nus.edu.sg/handle/10635/174385 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	MDM2 protein, human peptide protein binding protein MDM2 protein p53 TP53 protein, human binding site chemistry genetics human molecular dynamics mutation protein conformation protein secondary structure thermodynamics X ray crystallography Binding Sites Crystallography, X-Ray Humans Molecular Dynamics Simulation Mutation Peptides Protein Binding Protein Conformation Protein Structure, Secondary Proto-Oncogene Proteins c-mdm2 Thermodynamics Tumor Suppressor Protein p53
spellingShingle	MDM2 protein, human peptide protein binding protein MDM2 protein p53 TP53 protein, human binding site chemistry genetics human molecular dynamics mutation protein conformation protein secondary structure thermodynamics X ray crystallography Binding Sites Crystallography, X-Ray Humans Molecular Dynamics Simulation Mutation Peptides Protein Binding Protein Conformation Protein Structure, Secondary Proto-Oncogene Proteins c-mdm2 Thermodynamics Tumor Suppressor Protein p53 Yadahalli, S Li, J Lane, D.P Gosavi, S Verma, C.S Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
description	10.1038/s41598-017-15930-4
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Yadahalli, S Li, J Lane, D.P Gosavi, S Verma, C.S
format	Article
author	Yadahalli, S Li, J Lane, D.P Gosavi, S Verma, C.S
author_sort	Yadahalli, S
title	Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
title_short	Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
title_full	Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
title_fullStr	Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
title_full_unstemmed	Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
title_sort	characterizing the conformational landscape of mdm2-binding p53 peptides using molecular dynamics simulations
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174385
_version_	1800914236736536576

Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations

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