Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations

• Main Authors: Yadahalli, S, Li, J, Lane, D.P, Gosavi, S, Verma, C.S
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: MDM2 protein, human; peptide; protein binding; protein MDM2; protein p53; TP53 protein, human; binding site; chemistry; genetics; human; molecular dynamics; mutation; protein conformation; protein secondary structure; thermodynamics; X ray crystallography; Binding Sites; Crystallography, X-Ray; Humans; Molecular Dynamics Simulation; Mutation; Peptides; Protein Binding; Protein Conformation; Protein Structure, Secondary; Proto-Oncogene Proteins c-mdm2; Thermodynamics; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174385
• Institution: National University of Singapore

10.1038/s41598-017-15930-4