Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides

10.18632/oncotarget.8572

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Bibliographic Details
Main Authors:	Wei, S.J, Chee, S, Yurlova, L, Lane, D, Verma, C, Brown, C, Ghadessy, F
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	nutlin peptide inhibitor protein inhibitor protein MDM2 protein p53 unclassified drug antineoplastic agent MDM2 protein, human peptide protein binding TP53 protein, human animal cell Article BHK cell line binding affinity controlled study drug protein binding drug resistance fibroblast fluorescence polarization immunoprecipitation in vitro study molecular model mouse neoplasm nonhuman phenotype point mutation protein expression protein function protein purification Western blotting wild type animal antagonists and inhibitors binding site cell line chemistry drug design drug effects gene expression regulation genetics genotype human metabolism molecular mimicry pathology signal transduction structure activity relation Animals Antineoplastic Agents Binding Sites Cell Line Drug Design Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genotype Humans Mice Models, Molecular Molecular Mimicry Neoplasms Peptides Phenotype Point Mutation Protein Binding Proto-Oncogene Proteins c-mdm2 Signal Transduction Structure-Activity Relationship Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179927
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Institution:	National University of Singapore

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