Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides

10.18632/oncotarget.8572

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Main Authors:	Wei, S.J, Chee, S, Yurlova, L, Lane, D, Verma, C, Brown, C, Ghadessy, F
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	nutlin peptide inhibitor protein inhibitor protein MDM2 protein p53 unclassified drug antineoplastic agent MDM2 protein, human peptide protein binding TP53 protein, human animal cell Article BHK cell line binding affinity controlled study drug protein binding drug resistance fibroblast fluorescence polarization immunoprecipitation in vitro study molecular model mouse neoplasm nonhuman phenotype point mutation protein expression protein function protein purification Western blotting wild type animal antagonists and inhibitors binding site cell line chemistry drug design drug effects gene expression regulation genetics genotype human metabolism molecular mimicry pathology signal transduction structure activity relation Animals Antineoplastic Agents Binding Sites Cell Line Drug Design Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genotype Humans Mice Models, Molecular Molecular Mimicry Neoplasms Peptides Phenotype Point Mutation Protein Binding Proto-Oncogene Proteins c-mdm2 Signal Transduction Structure-Activity Relationship Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179927
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-179927
record_format	dspace
spelling	sg-nus-scholar.10635-1799272024-04-18T02:17:13Z Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides Wei, S.J Chee, S Yurlova, L Lane, D Verma, C Brown, C Ghadessy, F MEDICINE BIOLOGY (NU) nutlin peptide inhibitor protein inhibitor protein MDM2 protein p53 unclassified drug antineoplastic agent MDM2 protein, human peptide protein binding protein MDM2 protein p53 TP53 protein, human animal cell Article BHK cell line binding affinity controlled study drug protein binding drug resistance fibroblast fluorescence polarization immunoprecipitation in vitro study molecular model mouse neoplasm nonhuman phenotype point mutation protein binding protein expression protein function protein purification Western blotting wild type animal antagonists and inhibitors binding site cell line chemistry drug design drug effects gene expression regulation genetics genotype human metabolism molecular mimicry neoplasm pathology signal transduction structure activity relation Animals Antineoplastic Agents Binding Sites Cell Line Drug Design Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genotype Humans Mice Models, Molecular Molecular Mimicry Neoplasms Peptides Phenotype Point Mutation Protein Binding Proto-Oncogene Proteins c-mdm2 Signal Transduction Structure-Activity Relationship Tumor Suppressor Protein p53 10.18632/oncotarget.8572 Oncotarget 7 22 32232-32246 2020-10-26T05:08:17Z 2020-10-26T05:08:17Z 2016 Article Wei, S.J, Chee, S, Yurlova, L, Lane, D, Verma, C, Brown, C, Ghadessy, F (2016). Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides. Oncotarget 7 (22) : 32232-32246. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.8572 19492553 https://scholarbank.nus.edu.sg/handle/10635/179927 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	nutlin peptide inhibitor protein inhibitor protein MDM2 protein p53 unclassified drug antineoplastic agent MDM2 protein, human peptide protein binding protein MDM2 protein p53 TP53 protein, human animal cell Article BHK cell line binding affinity controlled study drug protein binding drug resistance fibroblast fluorescence polarization immunoprecipitation in vitro study molecular model mouse neoplasm nonhuman phenotype point mutation protein binding protein expression protein function protein purification Western blotting wild type animal antagonists and inhibitors binding site cell line chemistry drug design drug effects gene expression regulation genetics genotype human metabolism molecular mimicry neoplasm pathology signal transduction structure activity relation Animals Antineoplastic Agents Binding Sites Cell Line Drug Design Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genotype Humans Mice Models, Molecular Molecular Mimicry Neoplasms Peptides Phenotype Point Mutation Protein Binding Proto-Oncogene Proteins c-mdm2 Signal Transduction Structure-Activity Relationship Tumor Suppressor Protein p53
spellingShingle	nutlin peptide inhibitor protein inhibitor protein MDM2 protein p53 unclassified drug antineoplastic agent MDM2 protein, human peptide protein binding protein MDM2 protein p53 TP53 protein, human animal cell Article BHK cell line binding affinity controlled study drug protein binding drug resistance fibroblast fluorescence polarization immunoprecipitation in vitro study molecular model mouse neoplasm nonhuman phenotype point mutation protein binding protein expression protein function protein purification Western blotting wild type animal antagonists and inhibitors binding site cell line chemistry drug design drug effects gene expression regulation genetics genotype human metabolism molecular mimicry neoplasm pathology signal transduction structure activity relation Animals Antineoplastic Agents Binding Sites Cell Line Drug Design Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genotype Humans Mice Models, Molecular Molecular Mimicry Neoplasms Peptides Phenotype Point Mutation Protein Binding Proto-Oncogene Proteins c-mdm2 Signal Transduction Structure-Activity Relationship Tumor Suppressor Protein p53 Wei, S.J Chee, S Yurlova, L Lane, D Verma, C Brown, C Ghadessy, F Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides
description	10.18632/oncotarget.8572
author2	MEDICINE
author_facet	MEDICINE Wei, S.J Chee, S Yurlova, L Lane, D Verma, C Brown, C Ghadessy, F
format	Article
author	Wei, S.J Chee, S Yurlova, L Lane, D Verma, C Brown, C Ghadessy, F
author_sort	Wei, S.J
title	Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides
title_short	Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides
title_full	Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides
title_fullStr	Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides
title_full_unstemmed	Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides
title_sort	avoiding drug resistance through extended drug target interfaces: a case for stapled peptides
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179927
_version_	1800914573707968512

Avoiding drug resistance through extended drug target interfaces: A case for stapled peptides

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