Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

10.1038/s41598-017-02496-4

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Main Authors:	Koh, C.H, Wu, J, Chung, Y.Y, Liu, Z, Zhang, R.-R, Chong, K, Korzh, V, Ting, S, Oh, S, Shim, W, Tian, H.-Y, Wei, H
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid bufadienolide derivative bufalin CACNA1C protein, human calcium calcium channel L type calotropin cardenolide cardiac glycoside cinobufagin egtazic acid KCNH2 protein, human ouabain potassium channel HERG SCN1B protein, human SCN5A protein, human sodium channel Nav1.5 voltage gated sodium channel beta 1 subunit analogs and derivatives animal cardiac muscle cell cell differentiation cell line chemically induced CHO cell line Cricetulus cytology drug effect heart arrhythmia HEK293 cell line human human embryonic stem cell larva metabolism pathophysiology zebra fish Animals Arrhythmias, Cardiac Bufanolides Calcium Calcium Channels, L-Type Cardenolides Cardiac Glycosides Cell Differentiation Cell Line CHO Cells Egtazic Acid ERG1 Potassium Channel HEK293 Cells Human Embryonic Stem Cells Humans Larva Myocytes, Cardiac NAV1.5 Voltage-Gated Sodium Channel Ouabain Voltage-Gated Sodium Channel beta-1 Subunit Zebrafish
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174411
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1744112024-11-12T02:54:24Z Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides Koh, C.H Wu, J Chung, Y.Y Liu, Z Zhang, R.-R Chong, K Korzh, V Ting, S Oh, S Shim, W Tian, H.-Y Wei, H DUKE-NUS MEDICAL SCHOOL 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid bufadienolide derivative bufalin CACNA1C protein, human calcium calcium channel L type calotropin cardenolide cardiac glycoside cinobufagin egtazic acid KCNH2 protein, human ouabain potassium channel HERG SCN1B protein, human SCN5A protein, human sodium channel Nav1.5 voltage gated sodium channel beta 1 subunit analogs and derivatives animal cardiac muscle cell cell differentiation cell line chemically induced CHO cell line Cricetulus cytology drug effect heart arrhythmia HEK293 cell line human human embryonic stem cell larva metabolism pathophysiology zebra fish Animals Arrhythmias, Cardiac Bufanolides Calcium Calcium Channels, L-Type Cardenolides Cardiac Glycosides Cell Differentiation Cell Line CHO Cells Cricetulus Egtazic Acid ERG1 Potassium Channel HEK293 Cells Human Embryonic Stem Cells Humans Larva Myocytes, Cardiac NAV1.5 Voltage-Gated Sodium Channel Ouabain Voltage-Gated Sodium Channel beta-1 Subunit Zebrafish 10.1038/s41598-017-02496-4 Scientific Reports 7 1 2465 2020-09-04T03:37:15Z 2020-09-04T03:37:15Z 2017 Article Koh, C.H, Wu, J, Chung, Y.Y, Liu, Z, Zhang, R.-R, Chong, K, Korzh, V, Ting, S, Oh, S, Shim, W, Tian, H.-Y, Wei, H (2017). Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides. Scientific Reports 7 (1) : 2465. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-02496-4 2045-2322 https://scholarbank.nus.edu.sg/handle/10635/174411 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid bufadienolide derivative bufalin CACNA1C protein, human calcium calcium channel L type calotropin cardenolide cardiac glycoside cinobufagin egtazic acid KCNH2 protein, human ouabain potassium channel HERG SCN1B protein, human SCN5A protein, human sodium channel Nav1.5 voltage gated sodium channel beta 1 subunit analogs and derivatives animal cardiac muscle cell cell differentiation cell line chemically induced CHO cell line Cricetulus cytology drug effect heart arrhythmia HEK293 cell line human human embryonic stem cell larva metabolism pathophysiology zebra fish Animals Arrhythmias, Cardiac Bufanolides Calcium Calcium Channels, L-Type Cardenolides Cardiac Glycosides Cell Differentiation Cell Line CHO Cells Cricetulus Egtazic Acid ERG1 Potassium Channel HEK293 Cells Human Embryonic Stem Cells Humans Larva Myocytes, Cardiac NAV1.5 Voltage-Gated Sodium Channel Ouabain Voltage-Gated Sodium Channel beta-1 Subunit Zebrafish
spellingShingle	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid bufadienolide derivative bufalin CACNA1C protein, human calcium calcium channel L type calotropin cardenolide cardiac glycoside cinobufagin egtazic acid KCNH2 protein, human ouabain potassium channel HERG SCN1B protein, human SCN5A protein, human sodium channel Nav1.5 voltage gated sodium channel beta 1 subunit analogs and derivatives animal cardiac muscle cell cell differentiation cell line chemically induced CHO cell line Cricetulus cytology drug effect heart arrhythmia HEK293 cell line human human embryonic stem cell larva metabolism pathophysiology zebra fish Animals Arrhythmias, Cardiac Bufanolides Calcium Calcium Channels, L-Type Cardenolides Cardiac Glycosides Cell Differentiation Cell Line CHO Cells Cricetulus Egtazic Acid ERG1 Potassium Channel HEK293 Cells Human Embryonic Stem Cells Humans Larva Myocytes, Cardiac NAV1.5 Voltage-Gated Sodium Channel Ouabain Voltage-Gated Sodium Channel beta-1 Subunit Zebrafish Koh, C.H Wu, J Chung, Y.Y Liu, Z Zhang, R.-R Chong, K Korzh, V Ting, S Oh, S Shim, W Tian, H.-Y Wei, H Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
description	10.1038/s41598-017-02496-4
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Koh, C.H Wu, J Chung, Y.Y Liu, Z Zhang, R.-R Chong, K Korzh, V Ting, S Oh, S Shim, W Tian, H.-Y Wei, H
format	Article
author	Koh, C.H Wu, J Chung, Y.Y Liu, Z Zhang, R.-R Chong, K Korzh, V Ting, S Oh, S Shim, W Tian, H.-Y Wei, H
author_sort	Koh, C.H
title	Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
title_short	Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
title_full	Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
title_fullStr	Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
title_full_unstemmed	Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
title_sort	electronic supplementary materialidentification of a na+/k+-atpase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174411
_version_	1821231520859291648

Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

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