Electronic supplementary materialIdentification of a Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

• Main Authors: Koh, C.H, Wu, J, Chung, Y.Y, Liu, Z, Zhang, R.-R, Chong, K, Korzh, V, Ting, S, Oh, S, Shim, W, Tian, H.-Y, Wei, H
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; bufadienolide derivative; bufalin; CACNA1C protein, human; calcium; calcium channel L type; calotropin; cardenolide; cardiac glycoside; cinobufagin; egtazic acid; KCNH2 protein, human; ouabain; potassium channel HERG; SCN1B protein, human; SCN5A protein, human; sodium channel Nav1.5; voltage gated sodium channel beta 1 subunit; analogs and derivatives; animal; cardiac muscle cell; cell differentiation; cell line; chemically induced; CHO cell line; Cricetulus; cytology; drug effect; heart arrhythmia; HEK293 cell line; human; human embryonic stem cell; larva; metabolism; pathophysiology; zebra fish; Animals; Arrhythmias, Cardiac; Bufanolides; Calcium; Calcium Channels, L-Type; Cardenolides; Cardiac Glycosides; Cell Differentiation; Cell Line; CHO Cells; Egtazic Acid; ERG1 Potassium Channel; HEK293 Cells; Human Embryonic Stem Cells; Humans; Larva; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Ouabain; Voltage-Gated Sodium Channel beta-1 Subunit; Zebrafish
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174411
• Institution: National University of Singapore

10.1038/s41598-017-02496-4