Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice

10.1186/ar2810

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Main Authors:	Thwin M.-M., Douni E., Arjunan P., Kollias G., Kumar P.V., Gopalakrishnakone P.
Other Authors:	ANATOMY
Format:	Article
Published:	BioMed Central Ltd. 2020
Subjects:	antiflamin 2 antirheumatic agent celecoxib gelatinase A gelatinase B infliximab interleukin 1beta interleukin 6 interstitial collagenase matrix metalloproteinase matrix metalloproteinase inhibitor messenger RNA methotrexate mitogen activated protein kinase p38 phospholipase A2 group II phospholipase A2 group IIA phospholipase A2 inhibitor phospholipase inhibitor from python 18 stromelysin synthetic peptide tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 tumor necrosis factor tumor necrosis factor alpha unclassified drug varespladib enzyme inhibitor peptide secretory phospholipase A2 animal cell animal experiment animal model animal tissue ankle article cell stimulation concentration response controlled study drug effect drug efficacy drug mechanism enzyme activity enzyme inhibition enzyme linked immunosorbent assay enzyme phosphorylation enzyme synthesis fibroblast culture gene expression histopathology human human cell human tissue mouse nonhuman osteoarthritis protein expression real time polymerase chain reaction rheumatoid arthritis RNA transcription synoviocyte animal biosynthesis cytology drug antagonism fibroblast genetic transcription genetics metabolism reverse transcription polymerase chain reaction synovium transgenic mouse Animals Arthritis, Rheumatoid Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Fibroblasts Gene Expression Humans Interleukin-1beta Matrix Metalloproteinases Mice Mice, Transgenic Peptides Phospholipases A2, Secretory Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Transcription, Genetic Tumor Necrosis Factor-alpha
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174461
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1744612024-04-18T06:55:53Z Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice Thwin M.-M. Douni E. Arjunan P. Kollias G. Kumar P.V. Gopalakrishnakone P. ANATOMY ORTHOPAEDIC SURGERY antiflamin 2 antirheumatic agent celecoxib gelatinase A gelatinase B infliximab interleukin 1beta interleukin 6 interstitial collagenase matrix metalloproteinase matrix metalloproteinase inhibitor messenger RNA methotrexate mitogen activated protein kinase p38 phospholipase A2 group II phospholipase A2 group IIA phospholipase A2 inhibitor phospholipase inhibitor from python 18 stromelysin synthetic peptide tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 tumor necrosis factor tumor necrosis factor alpha unclassified drug varespladib enzyme inhibitor matrix metalloproteinase peptide secretory phospholipase A2 tumor necrosis factor alpha animal cell animal experiment animal model animal tissue ankle article cell stimulation concentration response controlled study drug effect drug efficacy drug mechanism enzyme activity enzyme inhibition enzyme linked immunosorbent assay enzyme phosphorylation enzyme synthesis fibroblast culture gene expression histopathology human human cell human tissue mouse nonhuman osteoarthritis protein expression real time polymerase chain reaction rheumatoid arthritis RNA transcription synoviocyte animal biosynthesis cytology drug antagonism fibroblast genetic transcription genetics metabolism reverse transcription polymerase chain reaction synovium transgenic mouse Animals Arthritis, Rheumatoid Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Fibroblasts Gene Expression Humans Interleukin-1beta Matrix Metalloproteinases Mice Mice, Transgenic Peptides Phospholipases A2, Secretory Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Transcription, Genetic Tumor Necrosis Factor-alpha 10.1186/ar2810 Arthritis Research and Therapy 11 5 R138 2020-09-04T06:38:24Z 2020-09-04T06:38:24Z 2009 Article Thwin M.-M., Douni E., Arjunan P., Kollias G., Kumar P.V., Gopalakrishnakone P. (2009). Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice. Arthritis Research and Therapy 11 (5) : R138. ScholarBank@NUS Repository. https://doi.org/10.1186/ar2810 14786354 https://scholarbank.nus.edu.sg/handle/10635/174461 BioMed Central Ltd. Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antiflamin 2 antirheumatic agent celecoxib gelatinase A gelatinase B infliximab interleukin 1beta interleukin 6 interstitial collagenase matrix metalloproteinase matrix metalloproteinase inhibitor messenger RNA methotrexate mitogen activated protein kinase p38 phospholipase A2 group II phospholipase A2 group IIA phospholipase A2 inhibitor phospholipase inhibitor from python 18 stromelysin synthetic peptide tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 tumor necrosis factor tumor necrosis factor alpha unclassified drug varespladib enzyme inhibitor matrix metalloproteinase peptide secretory phospholipase A2 tumor necrosis factor alpha animal cell animal experiment animal model animal tissue ankle article cell stimulation concentration response controlled study drug effect drug efficacy drug mechanism enzyme activity enzyme inhibition enzyme linked immunosorbent assay enzyme phosphorylation enzyme synthesis fibroblast culture gene expression histopathology human human cell human tissue mouse nonhuman osteoarthritis protein expression real time polymerase chain reaction rheumatoid arthritis RNA transcription synoviocyte animal biosynthesis cytology drug antagonism fibroblast genetic transcription genetics metabolism reverse transcription polymerase chain reaction synovium transgenic mouse Animals Arthritis, Rheumatoid Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Fibroblasts Gene Expression Humans Interleukin-1beta Matrix Metalloproteinases Mice Mice, Transgenic Peptides Phospholipases A2, Secretory Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Transcription, Genetic Tumor Necrosis Factor-alpha
spellingShingle	antiflamin 2 antirheumatic agent celecoxib gelatinase A gelatinase B infliximab interleukin 1beta interleukin 6 interstitial collagenase matrix metalloproteinase matrix metalloproteinase inhibitor messenger RNA methotrexate mitogen activated protein kinase p38 phospholipase A2 group II phospholipase A2 group IIA phospholipase A2 inhibitor phospholipase inhibitor from python 18 stromelysin synthetic peptide tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 tumor necrosis factor tumor necrosis factor alpha unclassified drug varespladib enzyme inhibitor matrix metalloproteinase peptide secretory phospholipase A2 tumor necrosis factor alpha animal cell animal experiment animal model animal tissue ankle article cell stimulation concentration response controlled study drug effect drug efficacy drug mechanism enzyme activity enzyme inhibition enzyme linked immunosorbent assay enzyme phosphorylation enzyme synthesis fibroblast culture gene expression histopathology human human cell human tissue mouse nonhuman osteoarthritis protein expression real time polymerase chain reaction rheumatoid arthritis RNA transcription synoviocyte animal biosynthesis cytology drug antagonism fibroblast genetic transcription genetics metabolism reverse transcription polymerase chain reaction synovium transgenic mouse Animals Arthritis, Rheumatoid Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Fibroblasts Gene Expression Humans Interleukin-1beta Matrix Metalloproteinases Mice Mice, Transgenic Peptides Phospholipases A2, Secretory Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Transcription, Genetic Tumor Necrosis Factor-alpha Thwin M.-M. Douni E. Arjunan P. Kollias G. Kumar P.V. Gopalakrishnakone P. Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
description	10.1186/ar2810
author2	ANATOMY
author_facet	ANATOMY Thwin M.-M. Douni E. Arjunan P. Kollias G. Kumar P.V. Gopalakrishnakone P.
format	Article
author	Thwin M.-M. Douni E. Arjunan P. Kollias G. Kumar P.V. Gopalakrishnakone P.
author_sort	Thwin M.-M.
title	Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
title_short	Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
title_full	Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
title_fullStr	Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
title_full_unstemmed	Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
title_sort	suppressive effect of secretory phospholipase a2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in htnftg mice
publisher	BioMed Central Ltd.
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174461
_version_	1800914246300598272

Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice

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