Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

10.1038/s41467-017-01392-9

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Main Authors:	Newman J.P., Wang G.Y., Arima K., Guan S.P., Waters M.R., Cavenee W.K., Pan E., Aliwarga E., Chong S.T., Kok C.Y.L., Endaya B.B., Habib A.A., Horibe T., Ng W.H., Ho I.A.W., Hui K.M., Kordula T., Lam P.Y.P.
Other Authors:	MEDICINE
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	epidermal growth factor receptor epidermal growth factor receptor v III interleukin 13 interleukin 13 receptor alpha2 messenger RNA phosphatidylinositol 3 kinase protein variant STAT3 protein unclassified drug epidermal growth factor receptor VIII mitogen activated protein kinase mitogen activated protein kinase kinase kinase Raf protein Ras protein brain cancer cells and cell components enzyme enzyme activity inhibitor protein animal experiment animal model Article astrocyte cancer patient carcinogenesis cell invasion cell migration cell proliferation cell viability controlled study cytoplasm enzyme activation glioblastoma glioma cell line human human cell in vitro study in vivo study major clinical study MAPK signaling mouse nonhuman Pi3K/Akt signaling primary tumor protein expression protein phosphorylation signal transduction tumor xenograft U-251MG cell line animal brain tumor cancer transplantation gene knockdown genetics metabolism mortality mutation pathology survival rate tumor cell line tumor invasion Animals Brain Neoplasms Cell Line, Tumor Cell Proliferation Extracellular Signal-Regulated MAP Kinases Gene Knockdown Techniques Glioblastoma Humans In Vitro Techniques Interleukin-13 Receptor alpha2 Subunit MAP Kinase Kinase Kinases Mice Mutation Neoplasm Invasiveness Neoplasm Transplantation raf Kinases ras Proteins Receptor, Epidermal Growth Factor RNA, Messenger Survival Rate
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174482
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1744822024-11-13T12:55:34Z Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme Newman J.P. Wang G.Y. Arima K. Guan S.P. Waters M.R. Cavenee W.K. Pan E. Aliwarga E. Chong S.T. Kok C.Y.L. Endaya B.B. Habib A.A. Horibe T. Ng W.H. Ho I.A.W. Hui K.M. Kordula T. Lam P.Y.P. MEDICINE PHYSIOLOGY DUKE-NUS MEDICAL SCHOOL BIOCHEMISTRY epidermal growth factor receptor epidermal growth factor receptor v III interleukin 13 interleukin 13 receptor alpha2 messenger RNA phosphatidylinositol 3 kinase protein variant STAT3 protein unclassified drug epidermal growth factor receptor epidermal growth factor receptor VIII interleukin 13 receptor alpha2 messenger RNA mitogen activated protein kinase mitogen activated protein kinase kinase kinase Raf protein Ras protein brain cancer cells and cell components enzyme enzyme activity inhibitor protein animal experiment animal model Article astrocyte cancer patient carcinogenesis cell invasion cell migration cell proliferation cell viability controlled study cytoplasm enzyme activation enzyme activity glioblastoma glioma cell line human human cell in vitro study in vivo study major clinical study MAPK signaling mouse nonhuman Pi3K/Akt signaling primary tumor protein expression protein phosphorylation signal transduction tumor xenograft U-251MG cell line animal brain tumor cancer transplantation gene knockdown genetics glioblastoma metabolism mortality mutation pathology survival rate tumor cell line tumor invasion Animals Brain Neoplasms Cell Line, Tumor Cell Proliferation Extracellular Signal-Regulated MAP Kinases Gene Knockdown Techniques Glioblastoma Humans In Vitro Techniques Interleukin-13 Receptor alpha2 Subunit MAP Kinase Kinase Kinases Mice Mutation Neoplasm Invasiveness Neoplasm Transplantation raf Kinases ras Proteins Receptor, Epidermal Growth Factor RNA, Messenger Survival Rate 10.1038/s41467-017-01392-9 Nature Communications 8 1 1913 2020-09-06T16:03:22Z 2020-09-06T16:03:22Z 2017 Article Newman J.P., Wang G.Y., Arima K., Guan S.P., Waters M.R., Cavenee W.K., Pan E., Aliwarga E., Chong S.T., Kok C.Y.L., Endaya B.B., Habib A.A., Horibe T., Ng W.H., Ho I.A.W., Hui K.M., Kordula T., Lam P.Y.P. (2017). Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme. Nature Communications 8 (1) : 1913. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-01392-9 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/174482 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	epidermal growth factor receptor epidermal growth factor receptor v III interleukin 13 interleukin 13 receptor alpha2 messenger RNA phosphatidylinositol 3 kinase protein variant STAT3 protein unclassified drug epidermal growth factor receptor epidermal growth factor receptor VIII interleukin 13 receptor alpha2 messenger RNA mitogen activated protein kinase mitogen activated protein kinase kinase kinase Raf protein Ras protein brain cancer cells and cell components enzyme enzyme activity inhibitor protein animal experiment animal model Article astrocyte cancer patient carcinogenesis cell invasion cell migration cell proliferation cell viability controlled study cytoplasm enzyme activation enzyme activity glioblastoma glioma cell line human human cell in vitro study in vivo study major clinical study MAPK signaling mouse nonhuman Pi3K/Akt signaling primary tumor protein expression protein phosphorylation signal transduction tumor xenograft U-251MG cell line animal brain tumor cancer transplantation gene knockdown genetics glioblastoma metabolism mortality mutation pathology survival rate tumor cell line tumor invasion Animals Brain Neoplasms Cell Line, Tumor Cell Proliferation Extracellular Signal-Regulated MAP Kinases Gene Knockdown Techniques Glioblastoma Humans In Vitro Techniques Interleukin-13 Receptor alpha2 Subunit MAP Kinase Kinase Kinases Mice Mutation Neoplasm Invasiveness Neoplasm Transplantation raf Kinases ras Proteins Receptor, Epidermal Growth Factor RNA, Messenger Survival Rate
spellingShingle	epidermal growth factor receptor epidermal growth factor receptor v III interleukin 13 interleukin 13 receptor alpha2 messenger RNA phosphatidylinositol 3 kinase protein variant STAT3 protein unclassified drug epidermal growth factor receptor epidermal growth factor receptor VIII interleukin 13 receptor alpha2 messenger RNA mitogen activated protein kinase mitogen activated protein kinase kinase kinase Raf protein Ras protein brain cancer cells and cell components enzyme enzyme activity inhibitor protein animal experiment animal model Article astrocyte cancer patient carcinogenesis cell invasion cell migration cell proliferation cell viability controlled study cytoplasm enzyme activation enzyme activity glioblastoma glioma cell line human human cell in vitro study in vivo study major clinical study MAPK signaling mouse nonhuman Pi3K/Akt signaling primary tumor protein expression protein phosphorylation signal transduction tumor xenograft U-251MG cell line animal brain tumor cancer transplantation gene knockdown genetics glioblastoma metabolism mortality mutation pathology survival rate tumor cell line tumor invasion Animals Brain Neoplasms Cell Line, Tumor Cell Proliferation Extracellular Signal-Regulated MAP Kinases Gene Knockdown Techniques Glioblastoma Humans In Vitro Techniques Interleukin-13 Receptor alpha2 Subunit MAP Kinase Kinase Kinases Mice Mutation Neoplasm Invasiveness Neoplasm Transplantation raf Kinases ras Proteins Receptor, Epidermal Growth Factor RNA, Messenger Survival Rate Newman J.P. Wang G.Y. Arima K. Guan S.P. Waters M.R. Cavenee W.K. Pan E. Aliwarga E. Chong S.T. Kok C.Y.L. Endaya B.B. Habib A.A. Horibe T. Ng W.H. Ho I.A.W. Hui K.M. Kordula T. Lam P.Y.P. Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
description	10.1038/s41467-017-01392-9
author2	MEDICINE
author_facet	MEDICINE Newman J.P. Wang G.Y. Arima K. Guan S.P. Waters M.R. Cavenee W.K. Pan E. Aliwarga E. Chong S.T. Kok C.Y.L. Endaya B.B. Habib A.A. Horibe T. Ng W.H. Ho I.A.W. Hui K.M. Kordula T. Lam P.Y.P.
format	Article
author	Newman J.P. Wang G.Y. Arima K. Guan S.P. Waters M.R. Cavenee W.K. Pan E. Aliwarga E. Chong S.T. Kok C.Y.L. Endaya B.B. Habib A.A. Horibe T. Ng W.H. Ho I.A.W. Hui K.M. Kordula T. Lam P.Y.P.
author_sort	Newman J.P.
title	Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
title_short	Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
title_full	Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
title_fullStr	Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
title_full_unstemmed	Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
title_sort	interleukin-13 receptor alpha 2 cooperates with egfrviii signaling to promote glioblastoma multiforme
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174482
_version_	1821200197289508864

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

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