Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

10.1038/ncomms15866

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Bibliographic Details
Main Authors:	Laviolette L.A., Mermoud J., Calvo I.A., Olson N., Boukhali M., Steinlein O.K., Roider E., Sattler E.C., Huang D., Teh B.T., Motamedi M., Haas W., Iliopoulos O.
Other Authors:	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format:	Note
Published:	Nature Publishing Group 2020
Subjects:	afatinib early endosome antigen 1 epidermal growth factor receptor estrone guanosine triphosphatase activating protein immunoglobulin G antibody lysosome associated membrane protein 1 protein kinase B rab7a protein scatter factor scatter factor receptor STAT3 protein tumor suppressor protein unclassified drug EGFR protein, human FLCN protein, human oncoprotein Rab protein Rab7 protein anatomy cancer cells and cell components enzyme enzyme activity gene gene expression growth inhibitor ligand mutation protein tumor animal experiment animal model animal tissue Article binding affinity cancer inhibition carboxy terminal sequence cell migration colorimetry confocal microscopy controlled study cytoplasm endosome genetic transfection human human cell human tissue immunofluorescence test immunoprecipitation lysosome mass spectrometry missense mutation mouse nonhuman protein degradation protein localization protein phosphorylation signal transduction tumor xenograft wild type animal Birt Hogg Dube syndrome C57BL mouse drug screening female genetics kidney tumor male metabolism pathology Schizosaccharomyces transgenic mouse tumor cell line Animals Birt-Hogg-Dube Syndrome Cell Line, Tumor Endosomes ErbB Receptors Female Humans Kidney Neoplasms Male Mice, Inbred C57BL Mice, Transgenic Mutation Proto-Oncogene Proteins rab GTP-Binding Proteins Signal Transduction Tumor Suppressor Proteins Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174490
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Institution:	National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/174490