Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

10.1038/ncomms15866

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Main Authors:	Laviolette L.A., Mermoud J., Calvo I.A., Olson N., Boukhali M., Steinlein O.K., Roider E., Sattler E.C., Huang D., Teh B.T., Motamedi M., Haas W., Iliopoulos O.
Other Authors:	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format:	Note
Published:	Nature Publishing Group 2020
Subjects:	afatinib early endosome antigen 1 epidermal growth factor receptor estrone guanosine triphosphatase activating protein immunoglobulin G antibody lysosome associated membrane protein 1 protein kinase B rab7a protein scatter factor scatter factor receptor STAT3 protein tumor suppressor protein unclassified drug EGFR protein, human FLCN protein, human oncoprotein Rab protein Rab7 protein anatomy cancer cells and cell components enzyme enzyme activity gene gene expression growth inhibitor ligand mutation protein tumor animal experiment animal model animal tissue Article binding affinity cancer inhibition carboxy terminal sequence cell migration colorimetry confocal microscopy controlled study cytoplasm endosome genetic transfection human human cell human tissue immunofluorescence test immunoprecipitation lysosome mass spectrometry missense mutation mouse nonhuman protein degradation protein localization protein phosphorylation signal transduction tumor xenograft wild type animal Birt Hogg Dube syndrome C57BL mouse drug screening female genetics kidney tumor male metabolism pathology Schizosaccharomyces transgenic mouse tumor cell line Animals Birt-Hogg-Dube Syndrome Cell Line, Tumor Endosomes ErbB Receptors Female Humans Kidney Neoplasms Male Mice, Inbred C57BL Mice, Transgenic Mutation Proto-Oncogene Proteins rab GTP-Binding Proteins Signal Transduction Tumor Suppressor Proteins Xenograft Model Antitumor Assays
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174490
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1744902023-11-01T07:48:16Z Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein Laviolette L.A. Mermoud J. Calvo I.A. Olson N. Boukhali M. Steinlein O.K. Roider E. Sattler E.C. Huang D. Teh B.T. Motamedi M. Haas W. Iliopoulos O. DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL afatinib early endosome antigen 1 epidermal growth factor receptor estrone guanosine triphosphatase activating protein immunoglobulin G antibody lysosome associated membrane protein 1 protein kinase B rab7a protein scatter factor scatter factor receptor STAT3 protein tumor suppressor protein unclassified drug EGFR protein, human epidermal growth factor receptor FLCN protein, human oncoprotein Rab protein Rab7 protein tumor suppressor protein anatomy cancer cells and cell components enzyme enzyme activity gene gene expression growth inhibitor ligand mutation protein tumor animal experiment animal model animal tissue Article binding affinity cancer inhibition carboxy terminal sequence cell migration colorimetry confocal microscopy controlled study cytoplasm endosome genetic transfection human human cell human tissue immunofluorescence test immunoprecipitation lysosome mass spectrometry missense mutation mouse nonhuman protein degradation protein localization protein phosphorylation signal transduction tumor xenograft wild type animal Birt Hogg Dube syndrome C57BL mouse drug screening female genetics kidney tumor male metabolism mutation pathology Schizosaccharomyces transgenic mouse tumor cell line Animals Birt-Hogg-Dube Syndrome Cell Line, Tumor Endosomes ErbB Receptors Female Humans Kidney Neoplasms Male Mice, Inbred C57BL Mice, Transgenic Mutation Proto-Oncogene Proteins rab GTP-Binding Proteins Schizosaccharomyces Signal Transduction Tumor Suppressor Proteins Xenograft Model Antitumor Assays 10.1038/ncomms15866 Nature Communications 8 15866 2020-09-06T16:04:46Z 2020-09-06T16:04:46Z 2017 Note Laviolette L.A., Mermoud J., Calvo I.A., Olson N., Boukhali M., Steinlein O.K., Roider E., Sattler E.C., Huang D., Teh B.T., Motamedi M., Haas W., Iliopoulos O. (2017). Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein. Nature Communications 8 : 15866. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms15866 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/174490 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	afatinib early endosome antigen 1 epidermal growth factor receptor estrone guanosine triphosphatase activating protein immunoglobulin G antibody lysosome associated membrane protein 1 protein kinase B rab7a protein scatter factor scatter factor receptor STAT3 protein tumor suppressor protein unclassified drug EGFR protein, human epidermal growth factor receptor FLCN protein, human oncoprotein Rab protein Rab7 protein tumor suppressor protein anatomy cancer cells and cell components enzyme enzyme activity gene gene expression growth inhibitor ligand mutation protein tumor animal experiment animal model animal tissue Article binding affinity cancer inhibition carboxy terminal sequence cell migration colorimetry confocal microscopy controlled study cytoplasm endosome genetic transfection human human cell human tissue immunofluorescence test immunoprecipitation lysosome mass spectrometry missense mutation mouse nonhuman protein degradation protein localization protein phosphorylation signal transduction tumor xenograft wild type animal Birt Hogg Dube syndrome C57BL mouse drug screening female genetics kidney tumor male metabolism mutation pathology Schizosaccharomyces transgenic mouse tumor cell line Animals Birt-Hogg-Dube Syndrome Cell Line, Tumor Endosomes ErbB Receptors Female Humans Kidney Neoplasms Male Mice, Inbred C57BL Mice, Transgenic Mutation Proto-Oncogene Proteins rab GTP-Binding Proteins Schizosaccharomyces Signal Transduction Tumor Suppressor Proteins Xenograft Model Antitumor Assays
spellingShingle	afatinib early endosome antigen 1 epidermal growth factor receptor estrone guanosine triphosphatase activating protein immunoglobulin G antibody lysosome associated membrane protein 1 protein kinase B rab7a protein scatter factor scatter factor receptor STAT3 protein tumor suppressor protein unclassified drug EGFR protein, human epidermal growth factor receptor FLCN protein, human oncoprotein Rab protein Rab7 protein tumor suppressor protein anatomy cancer cells and cell components enzyme enzyme activity gene gene expression growth inhibitor ligand mutation protein tumor animal experiment animal model animal tissue Article binding affinity cancer inhibition carboxy terminal sequence cell migration colorimetry confocal microscopy controlled study cytoplasm endosome genetic transfection human human cell human tissue immunofluorescence test immunoprecipitation lysosome mass spectrometry missense mutation mouse nonhuman protein degradation protein localization protein phosphorylation signal transduction tumor xenograft wild type animal Birt Hogg Dube syndrome C57BL mouse drug screening female genetics kidney tumor male metabolism mutation pathology Schizosaccharomyces transgenic mouse tumor cell line Animals Birt-Hogg-Dube Syndrome Cell Line, Tumor Endosomes ErbB Receptors Female Humans Kidney Neoplasms Male Mice, Inbred C57BL Mice, Transgenic Mutation Proto-Oncogene Proteins rab GTP-Binding Proteins Schizosaccharomyces Signal Transduction Tumor Suppressor Proteins Xenograft Model Antitumor Assays Laviolette L.A. Mermoud J. Calvo I.A. Olson N. Boukhali M. Steinlein O.K. Roider E. Sattler E.C. Huang D. Teh B.T. Motamedi M. Haas W. Iliopoulos O. Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
description	10.1038/ncomms15866
author2	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
author_facet	DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) Laviolette L.A. Mermoud J. Calvo I.A. Olson N. Boukhali M. Steinlein O.K. Roider E. Sattler E.C. Huang D. Teh B.T. Motamedi M. Haas W. Iliopoulos O.
format	Note
author	Laviolette L.A. Mermoud J. Calvo I.A. Olson N. Boukhali M. Steinlein O.K. Roider E. Sattler E.C. Huang D. Teh B.T. Motamedi M. Haas W. Iliopoulos O.
author_sort	Laviolette L.A.
title	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_short	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_full	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_fullStr	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_full_unstemmed	Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_sort	negative regulation of egfr signalling by the human folliculin tumour suppressor protein
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174490
_version_	1781792196673929216

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

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