Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis

• Main Authors: Koh K.X., Tan G.H., Low S.H.H., Omar M.F.M., Han M.J., Iacopetta B., Soo R., Beloueche-Babari M., Bhattacharya B., Soong R.
• Other Authors: DEAN'S OFFICE (MEDICINE)
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: 2 (2 amino 3 methoxyphenyl)chromone; 5 [2 (2,6 dimethylmorpholino) 4 morpholinopyrido[2,3 d]pyrimidin 7 yl] 2 methoxybenzenemethanol; alpelisib; dactolisib; docetaxel; epidermal growth factor receptor; gefitinib; glucose; glucose transporter 1; glutamine; lactic acid; mammalian target of rapamycin; mammalian target of rapamycin inhibitor; mitochondrial DNA; oxygen; phosphatidylinositol 3 kinase; phosphatidylinositol 3 kinase inhibitor; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; pictilisib; protein kinase B; reactive oxygen metabolite; S6 kinase; selumetinib; transcriptome; acquired drug resistance; Article; cell clone; cell metabolism; cell migration; controlled study; DNA sequence; drug resistance; enzyme inhibition; enzyme phosphorylation; G1 phase cell cycle checkpoint; glycolysis; human; human cell; mitochondrial DNA depletion; mutation; NCI-H1975 cell line; oxygen consumption; protein expression
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174500
• Institution: National University of Singapore

10.18632/oncotarget.22655