Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis
10.18632/oncotarget.22655
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2020
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sg-nus-scholar.10635-1745002024-04-03T07:38:27Z Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis Koh K.X. Tan G.H. Low S.H.H. Omar M.F.M. Han M.J. Iacopetta B. Soo R. Beloueche-Babari M. Bhattacharya B. Soong R. DEAN'S OFFICE (MEDICINE) NATIONAL UNIVERSITY MEDICAL INSTITUTES CANCER SCIENCE INSTITUTE OF SINGAPORE PATHOLOGY 2 (2 amino 3 methoxyphenyl)chromone 5 [2 (2,6 dimethylmorpholino) 4 morpholinopyrido[2,3 d]pyrimidin 7 yl] 2 methoxybenzenemethanol alpelisib dactolisib docetaxel epidermal growth factor receptor gefitinib glucose glucose transporter 1 glutamine lactic acid mammalian target of rapamycin mammalian target of rapamycin inhibitor mitochondrial DNA oxygen phosphatidylinositol 3 kinase phosphatidylinositol 3 kinase inhibitor phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase pictilisib protein kinase B reactive oxygen metabolite S6 kinase selumetinib transcriptome acquired drug resistance Article cell clone cell metabolism cell migration controlled study DNA sequence drug resistance enzyme inhibition enzyme phosphorylation G1 phase cell cycle checkpoint glycolysis human human cell mitochondrial DNA depletion mutation NCI-H1975 cell line oxygen consumption protein expression 10.18632/oncotarget.22655 Oncotarget 8 66 110133-110144 2020-09-06T16:07:04Z 2020-09-06T16:07:04Z 2017 Article Koh K.X., Tan G.H., Low S.H.H., Omar M.F.M., Han M.J., Iacopetta B., Soo R., Beloueche-Babari M., Bhattacharya B., Soong R. (2017). Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis. Oncotarget 8 (66) : 110133-110144. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.22655 1949-2553 https://scholarbank.nus.edu.sg/handle/10635/174500 Impact Journals LLC Unpaywall 20200831 |
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2 (2 amino 3 methoxyphenyl)chromone 5 [2 (2,6 dimethylmorpholino) 4 morpholinopyrido[2,3 d]pyrimidin 7 yl] 2 methoxybenzenemethanol alpelisib dactolisib docetaxel epidermal growth factor receptor gefitinib glucose glucose transporter 1 glutamine lactic acid mammalian target of rapamycin mammalian target of rapamycin inhibitor mitochondrial DNA oxygen phosphatidylinositol 3 kinase phosphatidylinositol 3 kinase inhibitor phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase pictilisib protein kinase B reactive oxygen metabolite S6 kinase selumetinib transcriptome acquired drug resistance Article cell clone cell metabolism cell migration controlled study DNA sequence drug resistance enzyme inhibition enzyme phosphorylation G1 phase cell cycle checkpoint glycolysis human human cell mitochondrial DNA depletion mutation NCI-H1975 cell line oxygen consumption protein expression |
| spellingShingle |
2 (2 amino 3 methoxyphenyl)chromone 5 [2 (2,6 dimethylmorpholino) 4 morpholinopyrido[2,3 d]pyrimidin 7 yl] 2 methoxybenzenemethanol alpelisib dactolisib docetaxel epidermal growth factor receptor gefitinib glucose glucose transporter 1 glutamine lactic acid mammalian target of rapamycin mammalian target of rapamycin inhibitor mitochondrial DNA oxygen phosphatidylinositol 3 kinase phosphatidylinositol 3 kinase inhibitor phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase pictilisib protein kinase B reactive oxygen metabolite S6 kinase selumetinib transcriptome acquired drug resistance Article cell clone cell metabolism cell migration controlled study DNA sequence drug resistance enzyme inhibition enzyme phosphorylation G1 phase cell cycle checkpoint glycolysis human human cell mitochondrial DNA depletion mutation NCI-H1975 cell line oxygen consumption protein expression Koh K.X. Tan G.H. Low S.H.H. Omar M.F.M. Han M.J. Iacopetta B. Soo R. Beloueche-Babari M. Bhattacharya B. Soong R. Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis |
| description |
10.18632/oncotarget.22655 |
| author2 |
DEAN'S OFFICE (MEDICINE) |
| author_facet |
DEAN'S OFFICE (MEDICINE) Koh K.X. Tan G.H. Low S.H.H. Omar M.F.M. Han M.J. Iacopetta B. Soo R. Beloueche-Babari M. Bhattacharya B. Soong R. |
| format |
Article |
| author |
Koh K.X. Tan G.H. Low S.H.H. Omar M.F.M. Han M.J. Iacopetta B. Soo R. Beloueche-Babari M. Bhattacharya B. Soong R. |
| author_sort |
Koh K.X. |
| title |
Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis |
| title_short |
Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis |
| title_full |
Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis |
| title_fullStr |
Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis |
| title_full_unstemmed |
Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis |
| title_sort |
acquired resistance to pi3k/mtor inhibition is associated with mitochondrial dna mutation and glycolysis |
| publisher |
Impact Journals LLC |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/174500 |
| _version_ |
1795374341223874560 |