Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury

• Main Authors: Chen B., Ng G., Gao Y., Low S.W., Sandanaraj E., Ramasamy B., Sekar S., Bhakoo K., Soong T.W., Nilius B., Tang C., Robins E.G., Goggi J., Liao P.
• Other Authors: DEAN'S OFFICE (MEDICINE)
• Format: Article
• Published: Springer 2020
• Subjects: claudin 1; claudin 2; Evans blue; hemoglobin; small interfering RNA; transient receptor potential channel M4; von Willebrand factor; enolase; fluorodeoxyglucose f 18; messenger RNA; transient receptor potential channel M; TRPM4 protein, rat; animal experiment; animal model; animal tissue; Article; blood brain barrier; brain capillary endothelial cell; brain edema; brain infarction; brain protection; brain tissue; cell survival; cerebrovascular accident; controlled study; extravasation; hemisphere; human; human cell; in vitro study; in vivo study; infarct volume; magnetic field; male; middle cerebral artery occlusion; motor performance; multimodal imaging; nerve cell growth; neuroimaging; non invasive procedure; nonhuman; nuclear magnetic resonance imaging; positron emission tomography; priority journal; protein expression; rat; reperfusion injury; stroke patient; animal; antagonists and inhibitors; cerebral artery disease; complication; disease model; gene expression regulation; genetics; hemispheric dominance; image processing; metabolism; microarray analysis; pathology; pathophysiology; physiology; procedures; Wistar rat; Animals; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Fluorodeoxyglucose F18; Functional Laterality; Gene Expression Regulation; Image Processing, Computer-Assisted; Infarction, Middle Cerebral Artery; Male; Microarray Analysis; Multimodal Imaging; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; RNA, Small Interfering; TRPM Cation Channels; von Willebrand Factor
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174510
• Institution: National University of Singapore

10.1007/s12975-018-0621-3