Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies
10.1084/jem.20171960
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Rockefeller University Press
2020
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sg-nus-scholar.10635-1751092024-04-22T03:33:48Z Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies Saei, A Palafox, M Benoukraf, T Kumari, N Jaynes, P.W Iyengar, P.V Muñoz?Couselo, E Nuciforo, P Cortés, J Nötzel, C Kumarakulasinghe, N.B Richard, J.L.C Isa, Z.F.B.A Pang, B Guzman, M Siqin, Z Yang, H Tam, W.L Serra, V Eichhorn, P.J.A CANCER SCIENCE INSTITUTE OF SINGAPORE DUKE-NUS MEDICAL SCHOOL PATHOLOGY BIOCHEMISTRY PHARMACOLOGY B Raf kinase F box/WD repeat containing protein 7 FBXW7 protein, human glycine rigosertib sulfone ubiquitin thiolesterase USP28 protein, human vemurafenib analogs and derivatives animal apoptosis deficiency down regulation drug effect drug resistance gene deletion HEK293 cell line human MAPK signaling melanoma metabolism mouse pathology prognosis protein degradation protein stability tumor cell line Animals Apoptosis Cell Line, Tumor Down-Regulation Drug Resistance, Neoplasm F-Box-WD Repeat-Containing Protein 7 Gene Deletion Glycine HEK293 Cells Humans MAP Kinase Signaling System Melanoma Mice Prognosis Protein Stability Proteolysis Proto-Oncogene Proteins B-raf Sulfones Ubiquitin Thiolesterase Vemurafenib 10.1084/jem.20171960 Journal of Experimental Medicine 215 7 1913-1928 2020-09-09T03:46:13Z 2020-09-09T03:46:13Z 2018 Article Saei, A, Palafox, M, Benoukraf, T, Kumari, N, Jaynes, P.W, Iyengar, P.V, Muñoz?Couselo, E, Nuciforo, P, Cortés, J, Nötzel, C, Kumarakulasinghe, N.B, Richard, J.L.C, Isa, Z.F.B.A, Pang, B, Guzman, M, Siqin, Z, Yang, H, Tam, W.L, Serra, V, Eichhorn, P.J.A (2018). Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies. Journal of Experimental Medicine 215 (7) : 1913-1928. ScholarBank@NUS Repository. https://doi.org/10.1084/jem.20171960 0022-1007 https://scholarbank.nus.edu.sg/handle/10635/175109 Rockefeller University Press Unpaywall 20200831 |
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B Raf kinase F box/WD repeat containing protein 7 FBXW7 protein, human glycine rigosertib sulfone ubiquitin thiolesterase USP28 protein, human vemurafenib analogs and derivatives animal apoptosis deficiency down regulation drug effect drug resistance gene deletion HEK293 cell line human MAPK signaling melanoma metabolism mouse pathology prognosis protein degradation protein stability tumor cell line Animals Apoptosis Cell Line, Tumor Down-Regulation Drug Resistance, Neoplasm F-Box-WD Repeat-Containing Protein 7 Gene Deletion Glycine HEK293 Cells Humans MAP Kinase Signaling System Melanoma Mice Prognosis Protein Stability Proteolysis Proto-Oncogene Proteins B-raf Sulfones Ubiquitin Thiolesterase Vemurafenib |
| spellingShingle |
B Raf kinase F box/WD repeat containing protein 7 FBXW7 protein, human glycine rigosertib sulfone ubiquitin thiolesterase USP28 protein, human vemurafenib analogs and derivatives animal apoptosis deficiency down regulation drug effect drug resistance gene deletion HEK293 cell line human MAPK signaling melanoma metabolism mouse pathology prognosis protein degradation protein stability tumor cell line Animals Apoptosis Cell Line, Tumor Down-Regulation Drug Resistance, Neoplasm F-Box-WD Repeat-Containing Protein 7 Gene Deletion Glycine HEK293 Cells Humans MAP Kinase Signaling System Melanoma Mice Prognosis Protein Stability Proteolysis Proto-Oncogene Proteins B-raf Sulfones Ubiquitin Thiolesterase Vemurafenib Saei, A Palafox, M Benoukraf, T Kumari, N Jaynes, P.W Iyengar, P.V Muñoz?Couselo, E Nuciforo, P Cortés, J Nötzel, C Kumarakulasinghe, N.B Richard, J.L.C Isa, Z.F.B.A Pang, B Guzman, M Siqin, Z Yang, H Tam, W.L Serra, V Eichhorn, P.J.A Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies |
| description |
10.1084/jem.20171960 |
| author2 |
CANCER SCIENCE INSTITUTE OF SINGAPORE |
| author_facet |
CANCER SCIENCE INSTITUTE OF SINGAPORE Saei, A Palafox, M Benoukraf, T Kumari, N Jaynes, P.W Iyengar, P.V Muñoz?Couselo, E Nuciforo, P Cortés, J Nötzel, C Kumarakulasinghe, N.B Richard, J.L.C Isa, Z.F.B.A Pang, B Guzman, M Siqin, Z Yang, H Tam, W.L Serra, V Eichhorn, P.J.A |
| format |
Article |
| author |
Saei, A Palafox, M Benoukraf, T Kumari, N Jaynes, P.W Iyengar, P.V Muñoz?Couselo, E Nuciforo, P Cortés, J Nötzel, C Kumarakulasinghe, N.B Richard, J.L.C Isa, Z.F.B.A Pang, B Guzman, M Siqin, Z Yang, H Tam, W.L Serra, V Eichhorn, P.J.A |
| author_sort |
Saei, A |
| title |
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies |
| title_short |
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies |
| title_full |
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies |
| title_fullStr |
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies |
| title_full_unstemmed |
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies |
| title_sort |
loss of usp28-mediated braf degradation drives resistance to raf cancer therapies |
| publisher |
Rockefeller University Press |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/175109 |
| _version_ |
1800914342128910336 |