Verapamil targets membrane energetics in mycobacterium tuberculosis

• Main Authors: Chen, C, Gardete, S, Jansen, R.S, Shetty, A, Dick, T, Rhee, K.Y, Dartoisa, V
• Other Authors: MEDICINE
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: ABC transporter subfamily B; aminoglycoside; amphophile; antimycobacterial agent; bacterial protein; bedaquiline; clofazimine; ethambutol; ethidium bromide; hygromycin B; isoniazid; linezolid; moxifloxacin; octamer transcription factor; pyrazinamide; rifampicin; streptomycin; tuberculostatic agent; verapamil; calcium channel blocking agent; quinoline derivative; animal cell; animal experiment; animal model; antibacterial activity; area under the curve; Article; bacterial clearance; bacterial membrane; bactericidal activity; concentration response; controlled study; drug accumulation; drug disposition; drug efficacy; drug mechanism; drug penetration; drug potentiation; drug targeting; drug uptake; fractional inhibitory concentration index; gene expression; human; human cell; in vitro study; in vivo study; macrophage; membrane potential; membrane vesicle; minimum inhibitory concentration; mouse; Mycobacterium tuberculosis; nonhuman; oxidative phosphorylation; phagocyte; pharmacodynamics; priority journal; animal; cell membrane; drug effect; female; metabolism; microbial sensitivity test; pathology; Animals; Antitubercular Agents; Calcium Channel Blockers; Cell Membrane; Clofazimine; Diarylquinolines; Drug Synergism; Female; Humans; Mice; Microbial Sensitivity Tests; Verapamil
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175116
• Institution: National University of Singapore

10.1128/AAC.02107-17