Verapamil targets membrane energetics in mycobacterium tuberculosis

10.1128/AAC.02107-17

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Main Authors:	Chen, C, Gardete, S, Jansen, R.S, Shetty, A, Dick, T, Rhee, K.Y, Dartoisa, V
Other Authors:	MEDICINE
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	ABC transporter subfamily B aminoglycoside amphophile antimycobacterial agent bacterial protein bedaquiline clofazimine ethambutol ethidium bromide hygromycin B isoniazid linezolid moxifloxacin octamer transcription factor pyrazinamide rifampicin streptomycin tuberculostatic agent verapamil calcium channel blocking agent quinoline derivative animal cell animal experiment animal model antibacterial activity area under the curve Article bacterial clearance bacterial membrane bactericidal activity concentration response controlled study drug accumulation drug disposition drug efficacy drug mechanism drug penetration drug potentiation drug targeting drug uptake fractional inhibitory concentration index gene expression human human cell in vitro study in vivo study macrophage membrane potential membrane vesicle minimum inhibitory concentration mouse Mycobacterium tuberculosis nonhuman oxidative phosphorylation phagocyte pharmacodynamics priority journal animal cell membrane drug effect female metabolism microbial sensitivity test pathology Animals Antitubercular Agents Calcium Channel Blockers Cell Membrane Clofazimine Diarylquinolines Drug Synergism Female Humans Mice Microbial Sensitivity Tests Verapamil
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175116
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1751162024-05-08T09:50:56Z Verapamil targets membrane energetics in mycobacterium tuberculosis Chen, C Gardete, S Jansen, R.S Shetty, A Dick, T Rhee, K.Y Dartoisa, V MEDICINE MICROBIOLOGY AND IMMUNOLOGY ABC transporter subfamily B aminoglycoside amphophile antimycobacterial agent bacterial protein bedaquiline clofazimine ethambutol ethidium bromide hygromycin B isoniazid linezolid moxifloxacin octamer transcription factor pyrazinamide rifampicin streptomycin tuberculostatic agent verapamil bedaquiline calcium channel blocking agent clofazimine quinoline derivative tuberculostatic agent verapamil animal cell animal experiment animal model antibacterial activity area under the curve Article bacterial clearance bacterial membrane bactericidal activity concentration response controlled study drug accumulation drug disposition drug efficacy drug mechanism drug penetration drug potentiation drug targeting drug uptake fractional inhibitory concentration index gene expression human human cell in vitro study in vivo study macrophage membrane potential membrane vesicle minimum inhibitory concentration mouse Mycobacterium tuberculosis nonhuman oxidative phosphorylation phagocyte pharmacodynamics priority journal animal cell membrane drug effect drug potentiation female metabolism microbial sensitivity test Mycobacterium tuberculosis pathology Animals Antitubercular Agents Calcium Channel Blockers Cell Membrane Clofazimine Diarylquinolines Drug Synergism Female Humans Mice Microbial Sensitivity Tests Mycobacterium tuberculosis Verapamil 10.1128/AAC.02107-17 Antimicrobial Agents and Chemotherapy 62 5 e02107-17 2020-09-09T04:09:10Z 2020-09-09T04:09:10Z 2018 Article Chen, C, Gardete, S, Jansen, R.S, Shetty, A, Dick, T, Rhee, K.Y, Dartoisa, V (2018). Verapamil targets membrane energetics in mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 62 (5) : e02107-17. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02107-17 0066-4804 https://scholarbank.nus.edu.sg/handle/10635/175116 American Society for Microbiology Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	ABC transporter subfamily B aminoglycoside amphophile antimycobacterial agent bacterial protein bedaquiline clofazimine ethambutol ethidium bromide hygromycin B isoniazid linezolid moxifloxacin octamer transcription factor pyrazinamide rifampicin streptomycin tuberculostatic agent verapamil bedaquiline calcium channel blocking agent clofazimine quinoline derivative tuberculostatic agent verapamil animal cell animal experiment animal model antibacterial activity area under the curve Article bacterial clearance bacterial membrane bactericidal activity concentration response controlled study drug accumulation drug disposition drug efficacy drug mechanism drug penetration drug potentiation drug targeting drug uptake fractional inhibitory concentration index gene expression human human cell in vitro study in vivo study macrophage membrane potential membrane vesicle minimum inhibitory concentration mouse Mycobacterium tuberculosis nonhuman oxidative phosphorylation phagocyte pharmacodynamics priority journal animal cell membrane drug effect drug potentiation female metabolism microbial sensitivity test Mycobacterium tuberculosis pathology Animals Antitubercular Agents Calcium Channel Blockers Cell Membrane Clofazimine Diarylquinolines Drug Synergism Female Humans Mice Microbial Sensitivity Tests Mycobacterium tuberculosis Verapamil
spellingShingle	ABC transporter subfamily B aminoglycoside amphophile antimycobacterial agent bacterial protein bedaquiline clofazimine ethambutol ethidium bromide hygromycin B isoniazid linezolid moxifloxacin octamer transcription factor pyrazinamide rifampicin streptomycin tuberculostatic agent verapamil bedaquiline calcium channel blocking agent clofazimine quinoline derivative tuberculostatic agent verapamil animal cell animal experiment animal model antibacterial activity area under the curve Article bacterial clearance bacterial membrane bactericidal activity concentration response controlled study drug accumulation drug disposition drug efficacy drug mechanism drug penetration drug potentiation drug targeting drug uptake fractional inhibitory concentration index gene expression human human cell in vitro study in vivo study macrophage membrane potential membrane vesicle minimum inhibitory concentration mouse Mycobacterium tuberculosis nonhuman oxidative phosphorylation phagocyte pharmacodynamics priority journal animal cell membrane drug effect drug potentiation female metabolism microbial sensitivity test Mycobacterium tuberculosis pathology Animals Antitubercular Agents Calcium Channel Blockers Cell Membrane Clofazimine Diarylquinolines Drug Synergism Female Humans Mice Microbial Sensitivity Tests Mycobacterium tuberculosis Verapamil Chen, C Gardete, S Jansen, R.S Shetty, A Dick, T Rhee, K.Y Dartoisa, V Verapamil targets membrane energetics in mycobacterium tuberculosis
description	10.1128/AAC.02107-17
author2	MEDICINE
author_facet	MEDICINE Chen, C Gardete, S Jansen, R.S Shetty, A Dick, T Rhee, K.Y Dartoisa, V
format	Article
author	Chen, C Gardete, S Jansen, R.S Shetty, A Dick, T Rhee, K.Y Dartoisa, V
author_sort	Chen, C
title	Verapamil targets membrane energetics in mycobacterium tuberculosis
title_short	Verapamil targets membrane energetics in mycobacterium tuberculosis
title_full	Verapamil targets membrane energetics in mycobacterium tuberculosis
title_fullStr	Verapamil targets membrane energetics in mycobacterium tuberculosis
title_full_unstemmed	Verapamil targets membrane energetics in mycobacterium tuberculosis
title_sort	verapamil targets membrane energetics in mycobacterium tuberculosis
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175116
_version_	1800914342721355776

Verapamil targets membrane energetics in mycobacterium tuberculosis

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