Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk

• Main Authors: Moreno-Moral, A, Bagnati, M, Koturan, S, Ko, J.-H, Fonseca, C, Harmston, N, Game, L, Martin, J, Ong, V, Abraham, D.J, Denton, C.P, Behmoaras, J, Petretto, E
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: BMJ Publishing Group 2020
• Subjects: gamma interferon antibody; lipopolysaccharide; GSDMA protein, human; transcriptome; tumor protein; Article; controlled study; disease association; down regulation; epigenetics; expression quantitative trait locus; gene expression regulation; genetic identification; genetic risk; genetic susceptibility; genetic transcription; genetic variability; genotype; glycolysis; human; hypoxia; immune response; macrophage; major clinical study; monocyte; mTOR signaling; priority journal; RNA sequence; systemic sclerosis; upregulation; adolescent; adult; case control study; child; cytology; female; genetic predisposition; genetics; genotyping technique; male; metabolism; pathology; preschool child; quantitative trait locus; risk factor; signal transduction; skin; young adult; Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotyping Techniques; Humans; Macrophages; Male; Neoplasm Proteins; Quantitative Trait Loci; Risk Factors; Scleroderma, Systemic; Signal Transduction; Skin; Transcriptome; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175120
• Institution: National University of Singapore

10.1136/annrheumdis-2017-212454