Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular
10.1128/AAC.01571-17
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American Society for Microbiology
2020
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sg-nus-scholar.10635-1751222024-05-08T09:51:52Z Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular Negatu, D.A Liu, J.J.J Zimmerman, M Kaya, F Dartois, V Aldrich, C.C Gengenbacher, M Dicka, T MEDICINE MICROBIOLOGY AND IMMUNOLOGY 2 (2,2,4,7 tetramethyl 1,2,3,4 tetrahydroquinolin 1 yl)ethan 1 ol hydrate 2 (3 chlorophenoxy)ethanethioamide 2 methyl 1h imidazole 4 carbothioamide 2 methyl 1h indol 5 amine 2,5 dimethyl 1 (2 thienylmethyl) 1 pyrrole 3 carboxylic acid 3 (4 fuorophenyl) 5 (methylsulfanyl) 1h pyrazole 4 (4 chlorophenoxy) 3,5 dimethyl 1 pyrazole 5 (4 chlorophenyl) n,n,2 trimethyl 3 furamide 5 phenylthiophene 2 carboxylic acid 6 chloro 1 (1,4 diazepan 1 yl) 1,3 benzothiazole 6 methyl 4 piperazino 2 (trifluoromethyl)quinoline 6,7,8,9 tetrahydrodibenzo[b,d]furan 2 amine 7 hydroxy 4 (trifluoromethyl) 2h chromen 2 one beta carboline carboxymethylcellulose dimethyl sulfoxide ethambutol ethyl 2 amino 5 methyl 4 phenylthiophene 3 carboxylate indolepropionic acid isoniazid isoquinoline 3 carboxylic acid macrogol 400 methyl 3 hydroxy 1 benzothiophene 2 carboxylate methyl isoquinoline 3 carboxylate pyrazinamide rifampicin tuberculostatic agent unclassified drug unindexed drug [2,2 bithiophene] 5 carboxylic acid [6 (piperidin 1 yl)pyridin 2 yl]methanamine propionic acid propionic acid derivative pyrazinamide tuberculostatic agent acute toxicity animal experiment animal model animal tissue antibacterial activity antitubercular activity area under the curve Article AUC (0-24 h) bacterial load bactericidal activity CC50 chemotherapy controlled study cytotoxicity drug bioavailability drug blood level drug delivery system drug determination drug efficacy drug half life drug mechanism drug potency drug screening drug tolerability elimination rate constant erythrocyte Escherichia coli female growth inhibition HC50 hemolysis Hep-G2 cell line human human cell hydrogen bond in vitro study in vivo study intestine flora limit of quantitation lung tuberculosis maximum concentration MIC50 MIC90 molecular library molecule monotherapy mouse Mycobacterium abscessus Mycobacterium smegmatis Mycobacterium tuberculosis nonhuman partition coefficient plasma concentration-time curve priority journal selectivity index single drug dose splenic tuberculosis Staphylococcus aureus THP-1 cell line whole cell animal Bagg albino mouse drug effect microbial sensitivity test Animals Antitubercular Agents Female Gastrointestinal Microbiome Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mycobacterium tuberculosis Propionates Pyrazinamide 10.1128/AAC.01571-17 Antimicrobial Agents and Chemotherapy 62 3 e01571-17 2020-09-09T04:10:38Z 2020-09-09T04:10:38Z 2018 Article Negatu, D.A, Liu, J.J.J, Zimmerman, M, Kaya, F, Dartois, V, Aldrich, C.C, Gengenbacher, M, Dicka, T (2018). Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular. Antimicrobial Agents and Chemotherapy 62 (3) : e01571-17. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.01571-17 0066-4804 https://scholarbank.nus.edu.sg/handle/10635/175122 American Society for Microbiology Unpaywall 20200831 |
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2 (2,2,4,7 tetramethyl 1,2,3,4 tetrahydroquinolin 1 yl)ethan 1 ol hydrate 2 (3 chlorophenoxy)ethanethioamide 2 methyl 1h imidazole 4 carbothioamide 2 methyl 1h indol 5 amine 2,5 dimethyl 1 (2 thienylmethyl) 1 pyrrole 3 carboxylic acid 3 (4 fuorophenyl) 5 (methylsulfanyl) 1h pyrazole 4 (4 chlorophenoxy) 3,5 dimethyl 1 pyrazole 5 (4 chlorophenyl) n,n,2 trimethyl 3 furamide 5 phenylthiophene 2 carboxylic acid 6 chloro 1 (1,4 diazepan 1 yl) 1,3 benzothiazole 6 methyl 4 piperazino 2 (trifluoromethyl)quinoline 6,7,8,9 tetrahydrodibenzo[b,d]furan 2 amine 7 hydroxy 4 (trifluoromethyl) 2h chromen 2 one beta carboline carboxymethylcellulose dimethyl sulfoxide ethambutol ethyl 2 amino 5 methyl 4 phenylthiophene 3 carboxylate indolepropionic acid isoniazid isoquinoline 3 carboxylic acid macrogol 400 methyl 3 hydroxy 1 benzothiophene 2 carboxylate methyl isoquinoline 3 carboxylate pyrazinamide rifampicin tuberculostatic agent unclassified drug unindexed drug [2,2 bithiophene] 5 carboxylic acid [6 (piperidin 1 yl)pyridin 2 yl]methanamine propionic acid propionic acid derivative pyrazinamide tuberculostatic agent acute toxicity animal experiment animal model animal tissue antibacterial activity antitubercular activity area under the curve Article AUC (0-24 h) bacterial load bactericidal activity CC50 chemotherapy controlled study cytotoxicity drug bioavailability drug blood level drug delivery system drug determination drug efficacy drug half life drug mechanism drug potency drug screening drug tolerability elimination rate constant erythrocyte Escherichia coli female growth inhibition HC50 hemolysis Hep-G2 cell line human human cell hydrogen bond in vitro study in vivo study intestine flora limit of quantitation lung tuberculosis maximum concentration MIC50 MIC90 molecular library molecule monotherapy mouse Mycobacterium abscessus Mycobacterium smegmatis Mycobacterium tuberculosis nonhuman partition coefficient plasma concentration-time curve priority journal selectivity index single drug dose splenic tuberculosis Staphylococcus aureus THP-1 cell line whole cell animal Bagg albino mouse drug effect microbial sensitivity test Animals Antitubercular Agents Female Gastrointestinal Microbiome Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mycobacterium tuberculosis Propionates Pyrazinamide |
| spellingShingle |
2 (2,2,4,7 tetramethyl 1,2,3,4 tetrahydroquinolin 1 yl)ethan 1 ol hydrate 2 (3 chlorophenoxy)ethanethioamide 2 methyl 1h imidazole 4 carbothioamide 2 methyl 1h indol 5 amine 2,5 dimethyl 1 (2 thienylmethyl) 1 pyrrole 3 carboxylic acid 3 (4 fuorophenyl) 5 (methylsulfanyl) 1h pyrazole 4 (4 chlorophenoxy) 3,5 dimethyl 1 pyrazole 5 (4 chlorophenyl) n,n,2 trimethyl 3 furamide 5 phenylthiophene 2 carboxylic acid 6 chloro 1 (1,4 diazepan 1 yl) 1,3 benzothiazole 6 methyl 4 piperazino 2 (trifluoromethyl)quinoline 6,7,8,9 tetrahydrodibenzo[b,d]furan 2 amine 7 hydroxy 4 (trifluoromethyl) 2h chromen 2 one beta carboline carboxymethylcellulose dimethyl sulfoxide ethambutol ethyl 2 amino 5 methyl 4 phenylthiophene 3 carboxylate indolepropionic acid isoniazid isoquinoline 3 carboxylic acid macrogol 400 methyl 3 hydroxy 1 benzothiophene 2 carboxylate methyl isoquinoline 3 carboxylate pyrazinamide rifampicin tuberculostatic agent unclassified drug unindexed drug [2,2 bithiophene] 5 carboxylic acid [6 (piperidin 1 yl)pyridin 2 yl]methanamine propionic acid propionic acid derivative pyrazinamide tuberculostatic agent acute toxicity animal experiment animal model animal tissue antibacterial activity antitubercular activity area under the curve Article AUC (0-24 h) bacterial load bactericidal activity CC50 chemotherapy controlled study cytotoxicity drug bioavailability drug blood level drug delivery system drug determination drug efficacy drug half life drug mechanism drug potency drug screening drug tolerability elimination rate constant erythrocyte Escherichia coli female growth inhibition HC50 hemolysis Hep-G2 cell line human human cell hydrogen bond in vitro study in vivo study intestine flora limit of quantitation lung tuberculosis maximum concentration MIC50 MIC90 molecular library molecule monotherapy mouse Mycobacterium abscessus Mycobacterium smegmatis Mycobacterium tuberculosis nonhuman partition coefficient plasma concentration-time curve priority journal selectivity index single drug dose splenic tuberculosis Staphylococcus aureus THP-1 cell line whole cell animal Bagg albino mouse drug effect microbial sensitivity test Animals Antitubercular Agents Female Gastrointestinal Microbiome Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mycobacterium tuberculosis Propionates Pyrazinamide Negatu, D.A Liu, J.J.J Zimmerman, M Kaya, F Dartois, V Aldrich, C.C Gengenbacher, M Dicka, T Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular |
| description |
10.1128/AAC.01571-17 |
| author2 |
MEDICINE |
| author_facet |
MEDICINE Negatu, D.A Liu, J.J.J Zimmerman, M Kaya, F Dartois, V Aldrich, C.C Gengenbacher, M Dicka, T |
| format |
Article |
| author |
Negatu, D.A Liu, J.J.J Zimmerman, M Kaya, F Dartois, V Aldrich, C.C Gengenbacher, M Dicka, T |
| author_sort |
Negatu, D.A |
| title |
Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular |
| title_short |
Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular |
| title_full |
Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular |
| title_fullStr |
Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular |
| title_full_unstemmed |
Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular |
| title_sort |
whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular |
| publisher |
American Society for Microbiology |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/175122 |
| _version_ |
1800914343185874944 |