N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway

• Main Authors: Mohan, C.D, Bharathkumar, H, Dukanya, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India, Rangappa, S, Shanmugam, M.K, Chinnathambi, A, Alharbi, S.A, Alahmadi, T.A, Bhattacharjee, A, Lobie, P.E, Deivasigamani, A, Hui, K.M, Sethi, G, Basappa, Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India, Rangappa, K.S, Kumar, A.P
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: 2 [3 (3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)propyl]isoindoline 1,3 dione; 4 (2,6 dichlorobenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one; 4 (4 isopropylbenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one; 4 (4 nitrobenzyl) 2h pyrido [3,2 b][1,4]oxazin 3(4h) one; 4 (cyclohexylmethyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one; 4 [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)methyl]benzonitrile; 4 [(6,6 dimethyl 4 phenyl 5,6 dihydro 4h 1,2 oxazin 3 yl)methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one; 4 [4 (tert butyl)benzyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one; 4 [[4 (4 chlorophenyl) 6,6 dimethyl 5,6 dihydro 4h 1,2 oxazin 3 yl]methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one; 4' [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3H) yl)methyl] [1,10 biphenyl] 2 carbonitrile; antineoplastic agent; DNA; immunoglobulin enhancer binding protein; liver protective agent; luciferase; transcription factor RelA; unclassified drug; animal experiment; animal model; animal tissue; antiproliferative activity; apoptosis; Article; cancer inhibition; cell viability; computer model; controlled study; dose response; down regulation; drug effect; drug efficacy; drug identification; drug potency; drug synthesis; female; gene expression regulation; HCCLM3 cell line; Hep-G2 cell line; Huh-7 cell line; IC50; liver cell carcinoma; luciferase gene; molecularly targeted therapy; mouse; nonhuman; pharmacological parameters; protein DNA binding; protein expression; protein phosphorylation; time dependence; tumor volume
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181171
• Institution: National University of Singapore

10.3389/fphar.2018.01125