GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers

• Main Authors: Rasheed, S.A.K, Leong, H.S, Lakshmanan, M, Raju, A, Dadlani, D, Chong, F.-T, Shannon, N.B, Rajarethinam, R, Skanthakumar, T, Tan, E.Y, Hwang, J.S.G, Lim, K.H, Tan, D.S.-W, Ceppi, P, Wang, M, Tergaonkar, V, Casey, P.J, Iyer, N.G
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: antineoplastic agent; cisplatin; cytotoxic agent; GNA13 protein; GNA13 protein inhibitor; guanine nucleotide binding protein; protein inhibitor; tumor marker; unclassified drug; guanine nucleotide binding protein alpha subunit; animal cell; animal experiment; animal model; animal tissue; Article; cancer growth; cancer patient; cancer prognosis; cancer resistance; cancer survival; carcinoma cell; controlled study; head and neck squamous cell carcinoma; human; human cell; in vitro study; in vivo study; metastasis; mouse; nonhuman; phenotype; priority journal; protein expression; protein function; randomized controlled trial; signal transduction; solid malignant neoplasm; tumor initiating phenotype; upregulation; animal; cell proliferation; cell transformation; drug effect; drug resistance; drug therapy; gene expression regulation; genetics; nonobese diabetic mouse; pathology; SCID mouse; tumor cell culture; Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Phenotype; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Tumor Cells, Cultured
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175123
• Institution: National University of Singapore

10.1038/s41388-017-0038-6