Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy

• Main Authors: Limviphuvadh, V, Tan, C.S, Konishi, F, Jenjaroenpun, P, Xiang, J.S, Kremenska, Y, Mu, Y.S, Syn, N, Lee, S.C, Soo, R.A, Eisenhaber, F, Maurer-Stroh, S, Yong, W.P
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: 5' nucleotidase; amino acid; gemcitabine; pyrimidine; antineoplastic agent; deoxycytidine; tumor marker; adult; amino acid sequence; Article; blood toxicity; cancer patient; cohort analysis; controlled study; crystal structure; drug response; female; genotype; human; major clinical study; male; molecular mechanics; neutropenia; non small cell lung cancer; overall survival; protein dephosphorylation; protein function; protein protein interaction; pyrimidine metabolism; Singaporean; single nucleotide polymorphism; survival analysis; thrombocytopenia; treatment outcome; analogs and derivatives; clinical trial; epidemiology; genetics; genotyping technique; lung tumor; mortality; personalized medicine; procedures; Singapore; young adult; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cohort Studies; Deoxycytidine; Female; Genotype; Genotyping Techniques; Humans; Lung Neoplasms; Male; Polymorphism, Single Nucleotide; Precision Medicine; Survival Analysis; Treatment Outcome; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175384
• Institution: National University of Singapore

10.1186/s12885-018-4471-x