Intracellular hyper-acidification potentiated by hydrogen sulfide mediates invasive and therapy resistant cancer cell death

• Main Authors: Lee Z.-W., Teo X.-Y., Song Z.J., Nin D.S., Novera W., Choo B.A., Dymock B.W., Moore P.K., Huang R.Y.-J., Deng L.-W.
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: antineoplastic agent; gyy 4137; hydrogen sulfide; lactic acid; metformin; simvastatin; unclassified drug; A-549 cell line; acidification; Article; bioenergy; cancer cell; cancer resistance; cell death; cell pH; cell viability; concentration response; controlled study; drug activity; drug cytotoxicity; drug potency; drug potentiation; drug response; DU145 cell line; glycolytic activity; HeLa cell line; intracellular hyperacidification; LNCaP cell line; MCF-7 cell line; MDA-MB-231 cell line; NCI-H1299 cell line; procedures concerning cells; radiosensitivity; SiHa cell line
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175420
• Institution: National University of Singapore

10.3389/fphar.2017.00763