Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons
10.1111/acel.12634
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sg-nus-scholar.10635-1754242024-04-04T01:11:41Z Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons Sharma, M Dierkes, T Sajikumar, S PHYSIOLOGY amyloid beta protein[1-42] brain derived neurotrophic factor brain derived neurotrophic factor receptor G9a GLP complex histone lysine methyltransferase unclassified drug 2 cyclohexyl n (1 isopropyl 4 piperidinyl) 6 methoxy 7 [3 (1 pyrrolidinyl)propoxy] 4 quinazolinamine amyloid beta protein amyloid beta-protein (1-42) azepine derivative brain derived neurotrophic factor brain derived neurotrophic factor receptor G9a protein, rat histone lysine methyltransferase n (1 benzyl 4 piperidinyl) 2 (hexahydro 4 methyl 1h 1,4 diazepin 1 yl) 6,7 dimethoxy 4 quinazolinamine peptide fragment quinazoline derivative TrkB protein, rat adult Alzheimer disease animal tissue Article catalysis controlled study epigenetic repression gene expression hippocampal CA1 region hippocampal slice long term potentiation male nerve cell plasticity nonhuman priority journal pyramidal nerve cell rat synaptic tagging and capture synaptic transmission upregulation animal antagonists and inhibitors chemically induced cognitive defect drug effect genetic epigenesis genetics hippocampal CA1 region long term potentiation metabolism microtomy pathology pathophysiology synapse tissue culture technique Wistar rat Amyloid beta-Peptides Animals Azepines Brain-Derived Neurotrophic Factor CA1 Region, Hippocampal Cognitive Dysfunction Epigenesis, Genetic Histone-Lysine N-Methyltransferase Long-Term Potentiation Male Microtomy Peptide Fragments Pyramidal Cells Quinazolines Rats Rats, Wistar Receptor, trkB Synapses Tissue Culture Techniques 10.1111/acel.12634 Aging Cell 16 5 1062-1072 2020-09-09T10:35:08Z 2020-09-09T10:35:08Z 2017 Article Sharma, M, Dierkes, T, Sajikumar, S (2017). Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons. Aging Cell 16 (5) : 1062-1072. ScholarBank@NUS Repository. https://doi.org/10.1111/acel.12634 1474-9718 https://scholarbank.nus.edu.sg/handle/10635/175424 Unpaywall 20200831 |
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amyloid beta protein[1-42] brain derived neurotrophic factor brain derived neurotrophic factor receptor G9a GLP complex histone lysine methyltransferase unclassified drug 2 cyclohexyl n (1 isopropyl 4 piperidinyl) 6 methoxy 7 [3 (1 pyrrolidinyl)propoxy] 4 quinazolinamine amyloid beta protein amyloid beta-protein (1-42) azepine derivative brain derived neurotrophic factor brain derived neurotrophic factor receptor G9a protein, rat histone lysine methyltransferase n (1 benzyl 4 piperidinyl) 2 (hexahydro 4 methyl 1h 1,4 diazepin 1 yl) 6,7 dimethoxy 4 quinazolinamine peptide fragment quinazoline derivative TrkB protein, rat adult Alzheimer disease animal tissue Article catalysis controlled study epigenetic repression gene expression hippocampal CA1 region hippocampal slice long term potentiation male nerve cell plasticity nonhuman priority journal pyramidal nerve cell rat synaptic tagging and capture synaptic transmission upregulation animal antagonists and inhibitors chemically induced cognitive defect drug effect genetic epigenesis genetics hippocampal CA1 region long term potentiation metabolism microtomy pathology pathophysiology synapse tissue culture technique Wistar rat Amyloid beta-Peptides Animals Azepines Brain-Derived Neurotrophic Factor CA1 Region, Hippocampal Cognitive Dysfunction Epigenesis, Genetic Histone-Lysine N-Methyltransferase Long-Term Potentiation Male Microtomy Peptide Fragments Pyramidal Cells Quinazolines Rats Rats, Wistar Receptor, trkB Synapses Tissue Culture Techniques |
| spellingShingle |
amyloid beta protein[1-42] brain derived neurotrophic factor brain derived neurotrophic factor receptor G9a GLP complex histone lysine methyltransferase unclassified drug 2 cyclohexyl n (1 isopropyl 4 piperidinyl) 6 methoxy 7 [3 (1 pyrrolidinyl)propoxy] 4 quinazolinamine amyloid beta protein amyloid beta-protein (1-42) azepine derivative brain derived neurotrophic factor brain derived neurotrophic factor receptor G9a protein, rat histone lysine methyltransferase n (1 benzyl 4 piperidinyl) 2 (hexahydro 4 methyl 1h 1,4 diazepin 1 yl) 6,7 dimethoxy 4 quinazolinamine peptide fragment quinazoline derivative TrkB protein, rat adult Alzheimer disease animal tissue Article catalysis controlled study epigenetic repression gene expression hippocampal CA1 region hippocampal slice long term potentiation male nerve cell plasticity nonhuman priority journal pyramidal nerve cell rat synaptic tagging and capture synaptic transmission upregulation animal antagonists and inhibitors chemically induced cognitive defect drug effect genetic epigenesis genetics hippocampal CA1 region long term potentiation metabolism microtomy pathology pathophysiology synapse tissue culture technique Wistar rat Amyloid beta-Peptides Animals Azepines Brain-Derived Neurotrophic Factor CA1 Region, Hippocampal Cognitive Dysfunction Epigenesis, Genetic Histone-Lysine N-Methyltransferase Long-Term Potentiation Male Microtomy Peptide Fragments Pyramidal Cells Quinazolines Rats Rats, Wistar Receptor, trkB Synapses Tissue Culture Techniques Sharma, M Dierkes, T Sajikumar, S Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons |
| description |
10.1111/acel.12634 |
| author2 |
PHYSIOLOGY |
| author_facet |
PHYSIOLOGY Sharma, M Dierkes, T Sajikumar, S |
| format |
Article |
| author |
Sharma, M Dierkes, T Sajikumar, S |
| author_sort |
Sharma, M |
| title |
Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons |
| title_short |
Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons |
| title_full |
Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons |
| title_fullStr |
Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons |
| title_full_unstemmed |
Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons |
| title_sort |
epigenetic regulation by g9a/glp complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/175424 |
| _version_ |
1795374379173937152 |