Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons

• Main Authors: Sharma, M, Dierkes, T, Sajikumar, S
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: amyloid beta protein[1-42]; brain derived neurotrophic factor; brain derived neurotrophic factor receptor; G9a GLP complex; histone lysine methyltransferase; unclassified drug; 2 cyclohexyl n (1 isopropyl 4 piperidinyl) 6 methoxy 7 [3 (1 pyrrolidinyl)propoxy] 4 quinazolinamine; amyloid beta protein; amyloid beta-protein (1-42); azepine derivative; G9a protein, rat; n (1 benzyl 4 piperidinyl) 2 (hexahydro 4 methyl 1h 1,4 diazepin 1 yl) 6,7 dimethoxy 4 quinazolinamine; peptide fragment; quinazoline derivative; TrkB protein, rat; adult; Alzheimer disease; animal tissue; Article; catalysis; controlled study; epigenetic repression; gene expression; hippocampal CA1 region; hippocampal slice; long term potentiation; male; nerve cell plasticity; nonhuman; priority journal; pyramidal nerve cell; rat; synaptic tagging and capture; synaptic transmission; upregulation; animal; antagonists and inhibitors; chemically induced; cognitive defect; drug effect; genetic epigenesis; genetics; metabolism; microtomy; pathology; pathophysiology; synapse; tissue culture technique; Wistar rat; Amyloid beta-Peptides; Animals; Azepines; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cognitive Dysfunction; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Long-Term Potentiation; Male; Microtomy; Peptide Fragments; Pyramidal Cells; Quinazolines; Rats; Rats, Wistar; Receptor, trkB; Synapses; Tissue Culture Techniques
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175424
• Institution: National University of Singapore

10.1111/acel.12634