Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission

• Main Authors: Shyamsunder, P, Esner, M, Barvalia, M, Wu, Y.J, Loja, T, Boon, H.B, Lleonart, M.E, Verma, R.S, Krejci, L, Lyakhovich, A
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: dynamin related protein 1; guanosine triphosphatase; hydroxymethylglutaryl coenzyme A reductase kinase; membrane protein; parkin; protein PINK1; reactive oxygen metabolite; small interfering RNA; unclassified drug; Article; autolysosome; autophagy; controlled study; disease association; disorders of mitochondrial functions; down regulation; Fanconi anemia; flow cytometry; fluorescence activated cell sorting; gene expression regulation; gene silencing; genetic transfection; human; human cell; intracellular signaling; lysosome; mitochondrial biogenesis; mitochondrial dynamics; mitochondrial fission; mitochondrial volume; mitophagy; molecular dynamics; oxidative stress; phenotype; scanning electron microscopy; transmission electron microscopy; upregulation; validation process; cell line; fluorescence microscopy; metabolism; mitochondrion; pathology; pathophysiology; rare disease; ultrastructure; Autophagy; Cell Line; Fanconi Anemia; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mitochondria; Mitochondrial Degradation; Mitochondrial Dynamics; Oxidative Stress; Rare Diseases; Reactive Oxygen Species
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175453
• Institution: National University of Singapore

10.18632/oncotarget.11161