Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

10.18632/oncotarget.9579

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Main Authors:	Kaminska, K.K, Bertrand, H.C, Tajima, H, Stafford, W.C, Cheng, Q, Chen, W, Wells, G, Arner, E.S.J, Chew, E.-H
Other Authors:	PHARMACY
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	antineoplastic agent apoptosis signal regulating kinase 1 caspase 3 glutathione peroxidase glutathione reductase indolin 2 one derivative mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oxidoreductase inhibitor selenocysteine stress activated protein kinase thioredoxin unclassified drug antioxidant indole derivative indolin-2-one juglone naphthoquinone reactive oxygen metabolite recombinant protein thioredoxin reductase TXN protein, human antineoplastic activity apoptosis Article breast carcinoma carboxy terminal sequence colorectal cancer drug selectivity drug structure drug targeting electrophilicity enzyme activation enzyme active site enzyme inhibition enzyme metabolism HCT116 cell line human human cell MCF 7 cell line oxidative stress protein cleavage signal transduction animal antagonists and inhibitors bovine chemistry drug design drug screening fibroblast HCT 116 cell line IC50 MCF-7 cell line metabolism mouse protein domain rat Animals Antineoplastic Agents Antioxidants Catalytic Domain Cattle Drug Design Drug Screening Assays, Antitumor Fibroblasts Glutathione Peroxidase Glutathione Reductase HCT116 Cells Humans Indoles Inhibitory Concentration 50 MCF-7 Cells Mice Naphthoquinones Oxidative Stress Protein Domains Rats Reactive Oxygen Species Recombinant Proteins Selenocysteine Thioredoxin-Disulfide Reductase Thioredoxins
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175457
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-175457
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spelling	sg-nus-scholar.10635-1754572024-04-05T09:03:16Z Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads Kaminska, K.K Bertrand, H.C Tajima, H Stafford, W.C Cheng, Q Chen, W Wells, G Arner, E.S.J Chew, E.-H PHARMACY antineoplastic agent apoptosis signal regulating kinase 1 caspase 3 glutathione peroxidase glutathione reductase indolin 2 one derivative mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oxidoreductase inhibitor selenocysteine stress activated protein kinase thioredoxin unclassified drug antineoplastic agent antioxidant glutathione peroxidase glutathione reductase indole derivative indolin-2-one juglone naphthoquinone reactive oxygen metabolite recombinant protein selenocysteine thioredoxin thioredoxin reductase TXN protein, human antineoplastic activity apoptosis Article breast carcinoma carboxy terminal sequence colorectal cancer drug selectivity drug structure drug targeting electrophilicity enzyme activation enzyme active site enzyme inhibition enzyme metabolism HCT116 cell line human human cell MCF 7 cell line oxidative stress protein cleavage signal transduction animal antagonists and inhibitors bovine chemistry drug design drug screening fibroblast HCT 116 cell line IC50 MCF-7 cell line metabolism mouse protein domain rat Animals Antineoplastic Agents Antioxidants Catalytic Domain Cattle Drug Design Drug Screening Assays, Antitumor Fibroblasts Glutathione Peroxidase Glutathione Reductase HCT116 Cells Humans Indoles Inhibitory Concentration 50 MCF-7 Cells Mice Naphthoquinones Oxidative Stress Protein Domains Rats Reactive Oxygen Species Recombinant Proteins Selenocysteine Thioredoxin-Disulfide Reductase Thioredoxins 10.18632/oncotarget.9579 Oncotarget 7 26 40233-40251 2020-09-10T01:45:29Z 2020-09-10T01:45:29Z 2016 Article Kaminska, K.K, Bertrand, H.C, Tajima, H, Stafford, W.C, Cheng, Q, Chen, W, Wells, G, Arner, E.S.J, Chew, E.-H (2016). Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads. Oncotarget 7 (26) : 40233-40251. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.9579 19492553 https://scholarbank.nus.edu.sg/handle/10635/175457 Impact Journals LLC Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antineoplastic agent apoptosis signal regulating kinase 1 caspase 3 glutathione peroxidase glutathione reductase indolin 2 one derivative mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oxidoreductase inhibitor selenocysteine stress activated protein kinase thioredoxin unclassified drug antineoplastic agent antioxidant glutathione peroxidase glutathione reductase indole derivative indolin-2-one juglone naphthoquinone reactive oxygen metabolite recombinant protein selenocysteine thioredoxin thioredoxin reductase TXN protein, human antineoplastic activity apoptosis Article breast carcinoma carboxy terminal sequence colorectal cancer drug selectivity drug structure drug targeting electrophilicity enzyme activation enzyme active site enzyme inhibition enzyme metabolism HCT116 cell line human human cell MCF 7 cell line oxidative stress protein cleavage signal transduction animal antagonists and inhibitors bovine chemistry drug design drug screening fibroblast HCT 116 cell line IC50 MCF-7 cell line metabolism mouse protein domain rat Animals Antineoplastic Agents Antioxidants Catalytic Domain Cattle Drug Design Drug Screening Assays, Antitumor Fibroblasts Glutathione Peroxidase Glutathione Reductase HCT116 Cells Humans Indoles Inhibitory Concentration 50 MCF-7 Cells Mice Naphthoquinones Oxidative Stress Protein Domains Rats Reactive Oxygen Species Recombinant Proteins Selenocysteine Thioredoxin-Disulfide Reductase Thioredoxins
spellingShingle	antineoplastic agent apoptosis signal regulating kinase 1 caspase 3 glutathione peroxidase glutathione reductase indolin 2 one derivative mitogen activated protein kinase p38 nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase oxidoreductase inhibitor selenocysteine stress activated protein kinase thioredoxin unclassified drug antineoplastic agent antioxidant glutathione peroxidase glutathione reductase indole derivative indolin-2-one juglone naphthoquinone reactive oxygen metabolite recombinant protein selenocysteine thioredoxin thioredoxin reductase TXN protein, human antineoplastic activity apoptosis Article breast carcinoma carboxy terminal sequence colorectal cancer drug selectivity drug structure drug targeting electrophilicity enzyme activation enzyme active site enzyme inhibition enzyme metabolism HCT116 cell line human human cell MCF 7 cell line oxidative stress protein cleavage signal transduction animal antagonists and inhibitors bovine chemistry drug design drug screening fibroblast HCT 116 cell line IC50 MCF-7 cell line metabolism mouse protein domain rat Animals Antineoplastic Agents Antioxidants Catalytic Domain Cattle Drug Design Drug Screening Assays, Antitumor Fibroblasts Glutathione Peroxidase Glutathione Reductase HCT116 Cells Humans Indoles Inhibitory Concentration 50 MCF-7 Cells Mice Naphthoquinones Oxidative Stress Protein Domains Rats Reactive Oxygen Species Recombinant Proteins Selenocysteine Thioredoxin-Disulfide Reductase Thioredoxins Kaminska, K.K Bertrand, H.C Tajima, H Stafford, W.C Cheng, Q Chen, W Wells, G Arner, E.S.J Chew, E.-H Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
description	10.18632/oncotarget.9579
author2	PHARMACY
author_facet	PHARMACY Kaminska, K.K Bertrand, H.C Tajima, H Stafford, W.C Cheng, Q Chen, W Wells, G Arner, E.S.J Chew, E.-H
format	Article
author	Kaminska, K.K Bertrand, H.C Tajima, H Stafford, W.C Cheng, Q Chen, W Wells, G Arner, E.S.J Chew, E.-H
author_sort	Kaminska, K.K
title	Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
title_short	Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
title_full	Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
title_fullStr	Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
title_full_unstemmed	Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
title_sort	indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
publisher	Impact Journals LLC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175457
_version_	1800914371324411904

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

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